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7-甲氧基-4-(4-甲氧基苯基)-1,2-二氢萘 | 79822-57-4

中文名称
7-甲氧基-4-(4-甲氧基苯基)-1,2-二氢萘
中文别名
——
英文名称
7-methoxy-4-(4-methoxyphenyl)-1,2-dihydronaphthalene
英文别名
7-methoxy-4-(4-methoxy-phenyl)-1,2-dihydro-naphthalene;7-Methoxy-4-(4-methoxy-phenyl)-1,2-dihydro-naphthalin;3,4-dihydro-6-methoxy-1-(4-methoxyphenyl)naphthalene
7-甲氧基-4-(4-甲氧基苯基)-1,2-二氢萘化学式
CAS
79822-57-4
化学式
C18H18O2
mdl
——
分子量
266.34
InChiKey
VOSRGDRDAOZSQU-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4.1
  • 重原子数:
    20
  • 可旋转键数:
    3
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.22
  • 拓扑面积:
    18.5
  • 氢给体数:
    0
  • 氢受体数:
    2

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量
    • 1
    • 2

反应信息

  • 作为反应物:
    参考文献:
    名称:
    Propenyl carboxamide derivatives as antagonists of platelet-activating factor
    摘要:
    A series of N-[4-(3-pyridinyl)butyl] 3-substituted propenyl carboxamide derivatives bearing an unsaturated bicyclic moiety in the 3-position was prepared and evaluated for PAF (platelet activating factor) antagonist activity. These compounds represent conformationally constrained direct analogues of the corresponding potent 5-aryl-pentadienecarboxamides (5). Most of the new compounds were active in a PAF-binding assay employing whole, washed dog platelets as the receptor source and inhibited PAF-induced bronchoconstriction in guinea pigs after intravenous administration. However, oral activity in the PAF-induced bronchoconstriction model was highly sensitive to the nature and substitution of the bicyclic ring system. The most interesting compounds included [R-(E)]-(1-butyl-6-methoxy-2-naphthyl)-N-[1-methyl-4-(3- pyridinyl)butyl]-2-propenamide (4b), [R-(E)]-(3-butyl-6-methoxy-2- benzo[b]thiophene-yl)-N-[1-methyl-4-(3-pyridinyl)butyl]-2-propenamide (4k), and [R-(E)]-(3-butyl-6-methoxy-1-methyl-2-indoly)-N-[1-ethyl-4- (3-pyridinyl)butyl]-2-propenamide (4l) which inhibited PAF-induced broncho-constriction in guinea pigs with IC50s of 3.0-5.4 mg/kg, when the animals were challenged 2 h after drug treatment. They were also highly effective 6 h after a 50 mg/kg oral dose. This study supports the notion that the key remote aromatic ring present in the 5-arylpentadienecarboxamides (5) is preferentially coplanar with the diene system for good PAF antagonist activity.
    DOI:
    10.1021/jm00172a029
  • 作为产物:
    描述:
    [1-(4-甲氧基苯基)-4-甲氧基亚苄基]环丙烷 在 C42H50Cl2N4Pd 、 1,3-双(2,4,6-三甲基苯基)氯化咪唑 作用下, 以 N,N-二甲基乙酰胺 为溶剂, 反应 12.0h, 以55%的产率得到7-甲氧基-4-(4-甲氧基苯基)-1,2-二氢萘
    参考文献:
    名称:
    Intramolecular Cycloisomerization of Aryl-Substituted Alkylidenecyclo­propanes via NHC Palladium-Catalyzed Cascade C-C Bond Cleavage/C-H Activation/C-C Bond Formation
    摘要:
    本研究描述了一种定义明确的 N-杂环碳烯(NHC)钯催化的芳基取代亚烷基环丙烷(ACP)到 1-芳基二氢萘的分子内环化反应。研究发现,NHC 盐会抑制同质烯丙基钯中间体中的δ-酸酐消除,这可能会导致不必要的烯烃形成。提出了环异构化的合理机制。
    DOI:
    10.1055/s-2008-1078404
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文献信息

  • Pyridine compounds which are useful in treating a disease state
    申请人:Hoffman-La Roche Inc.
    公开号:US04927838A1
    公开(公告)日:1990-05-22
    The invention relates to compounds of the formula ##STR1## wherein Y and Y' are hydrogen or taken together are O or S, *A is paraphenylene or *----(CH.sub.2).sub.n --(X).sub.s --(CH.sub.2).sub.r ----, X is O, S or --CH.dbd.CH--, n or r, independently, are integers from 0 to 3, m is an integer from 0 to 1, s is an integer from 0 to 1, provided that when s is 1, n+m must be at least 2, t is an integer from 0 to 10, R.sub.1 and R.sub.2, independently, are lower alkyl, lower alkenyl or aryl, or one of R.sub.1 or R.sub.2 is hydrogen and the other is ##STR2## wherein W is ##STR3## --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --, O, S, or ##STR4## and X.sub.1 is lower alkyl, phenyl unsubstituted or mono-, di- or trisubstituted by lower alkoxy, lower alkyl or halogen, and X.sub.2, X.sub.3 and X.sub.4, independently, are hydrogen, lower alkyl, lower alkoxy or halogen, R.sub.3 is hydrogen, lower alkyl or aryl, R.sub.4 is hydrogen, lower alkyl, aryl, aryl-lower alkyl or acyl, R.sub.5 is hydrogen or lower alkyl, R.sub.6 is hydrogen, lower alkyl, cycloalkyl, Het-lower alkyl or aryl, Het is a monocyclic 6-membered heteroaromatic radical containing one or two nitrogen atoms, which radical may be substituted by lower alkyl, halogen or aryl, and the asterisk denotes the point of attachment, and when R.sub.5 and R.sub.6 are different, their enantiomers and racemic mixtures thereof, when R.sub.1 and R.sub.2 are different, their geometric isomers, and pharmaceutically acceptable acid addition salts thereof.
    该发明涉及以下式的化合物##STR1##其中Y和Y'是氢或一起取O或S,*A是对苯二甲基或*----(CH.sub.2).sub.n --(X).sub.s --(CH.sub.2).sub.r ----,X是O、S或--CH.dbd.CH--,n或r独立地是0到3的整数,m是0到1的整数,s是0到1的整数,但当s为1时,n+m必须至少为2,t是0到10的整数,R.sub.1和R.sub.2独立地是较低的烷基、较低的烯烃基或芳基,或者R.sub.1或R.sub.2中的一个是氢,另一个是##STR2##其中W是##STR3##--CH.sub.2 --CH.sub.2 --,--CH.sub.2 --,O,S,或##STR4##,X.sub.1是较低的烷基,苯基未取代或被较低的烷氧基、较低的烷基或卤素单取代、双取代或三取代,X.sub.2、X.sub.3和X.sub.4独立地是氢、较低的烷基、较低的烷氧基或卤素,R.sub.3是氢、较低的烷基或芳基,R.sub.4是氢、较低的烷基、芳基、芳基-较低的烷基或酰基,R.sub.5是氢或较低的烷基,R.sub.6是氢、较低的烷基、环烷基、Het-较低的烷基或芳基,Het是含有一个或两个氮原子的单环6-成员杂芳基,该基团可以被较低的烷基、卤素或芳基取代,星号表示连接点,当R.sub.5和R.sub.6不同时,它们的对映异构体和外消旋混合物,当R.sub.1和R.sub.2不同时,它们的几何异构体,以及其药学上可接受的酸盐。
  • Synthesis of 1,1-Diarylethylenes via Efficient Iron/Copper Co-Catalyzed Coupling of 1-Arylvinyl Halides with Grignard Reagents
    作者:Abdallah Hamze、Jean-Daniel Brion、Mouad Alami
    DOI:10.1021/ol3010112
    日期:2012.6.1
    An efficient access to 1,1-diarylethylenes of biological interest by coupling functionalized aryl Grignard reagents and 1-arylvinyl halides in the presence of FeCl3/CuTC is described. This bimetallic system proved to be superior to the use of Fe or Cu catalyst alone. The synthetic utility of this protocol is illustrated in the field of steroid chemistry.
    描述了通过在FeCl 3 / CuTC存在下偶联官能化的芳基格氏试剂和1-芳基乙烯基卤化物来有效获得生物学上感兴趣的1,1-二芳基乙烯。事实证明,这种双金属系统优于单独使用Fe或Cu催化剂。该方案的合成用途在类固醇化学领域得到了说明。
  • Hydroxy-substituierte Phenyltetraline: Verbindungen mit Affinität zu Östrogen- und Androgenrezeptoren
    作者:Martin R. Schneider、Claus Dieter Schiller
    DOI:10.1002/ardp.19903230106
    日期:——
    nur Verbindungen vom Flutamid‐Typ beschrieben. Zur Auffindung neuer Strukturen mit Affinität zum Androgenrezeptor und antiandrogener Wirkung wurden daher fünf neue Hydroxy‐substituierte Phenyltetraline hergestellt und getestet. Die Synthese erfolgte durch Umsetzung der entspr. 1‐Tetralone mit den jeweiligen Phenylmagnesiumbromiden, durch Wasserabspaltung der erhaltenen Carbinole, Hydrierung und Etherspaltung
    大多数非甾体类抗雄激素仅含有氟他胺类化合物。为了寻找对雄激素受体具有亲和力和抗雄激素作用的新结构,生产并测试了五种新的羟基取代的苯基萘满。合成是通过将相应的 1-四氢萘酮与相应的苯基溴化镁反应,通过从获得的甲醇中分离出水,氢化和醚的分离来进行的。除了对雌激素受体的预期亲和力之外,6-OH、4'-OH-取代的化合物11还特别显示出对雄激素受体的亲和力。虽然所研究的物质都没有明显的雌激素作用,但 11 和 15 (6-OH, 3'-OH) 具有抗雌激素作用。没有雄激素特性。成年时,在完整小鼠中,11 和 15 对精囊重量产生显着抑制,同时睾酮水平降低。由于在去势的雄激素替代动物中只有相对较弱的直接抗雄激素作用,这些苯基萘满的抗雄激素作用更多地基于对睾酮生物合成的干预,而不是直接受体介导的作用。
  • Naphthopyrans annelated in C5-C6, their preparation and compositions and (CO)polymer matrices containing them
    申请人:——
    公开号:US20020197562A1
    公开(公告)日:2002-12-26
    The present invention relates to novel compounds of the naphthopyran type which have an annelated carbocycle in position 5,6. These compounds are of formula (I) given below: 1 in which A is an alicyclic ring which is optionally annelated with an aromatic ring and in which two adjacent R 3 can together form at least one ring, for example a benzo group. These compounds (I) possess interesting photochromic properties. The invention also relates to the method of preparing these compounds (I), as well as their applications as photochromes and compositions and (co)polymer matrices comprising them.
    本发明涉及一种新型的萘并吡喃类化合物,其在5,6位具有一个环合的碳环。这些化合物的化学式如下:1其中A是一个脂环,可以与芳香环环合,在其中相邻的两个R3可以共同形成至少一个环,例如苯环。这些化合物(I)具有有趣的光致变色性质。本发明还涉及制备这些化合物(I)的方法,以及它们作为光致变色剂的应用、包含它们的组合物和(共)聚合物基体。
  • Substituted alkene carboxylic acid amides and derivatives
    申请人:F. HOFFMANN-LA ROCHE AG
    公开号:EP0298466A2
    公开(公告)日:1989-01-11
    There are described compounds of the general formula wherein Y and Y′ are hydrogen or taken together are O or S, *A is paraphenylene or *-(CH₂)n-(X)s-(CH₂)r-, X is O, S or -CH=CH-, n and r, independently are integers from 0 to 3, m is the integer 0 or 1, s is the integer 0 or 1, provided that when s is 1, n+m is at least 2, t is an integer from 0 to 10, R₁ and R₂, independently, are lower alkyl, lower alkenyl or aryl, or one of R₁ and R₂ is hydrogen and the other is W is -CX₃=CX₄-, -CH₂-CH₂-, -CH₂-, O, S or -NX₅-, X₁ is lower alkyl, phenyl or phenyl with up to 3 substituents selected from lower alkoxy, lower alkyl and halogen, X₂, X₃ and X₄, independently, are hydrogen, lower alkyl, lower alkoxy or halogen, X₅ is lower alkyl, R₃ is hydrogen, lower alkyl or aryl, R₄ is hydrogen, lower alkyl, aryl, aryl-lower alkyl or acyl, R₅ is hydrogen or lower alkyl, R₆ is hydrogen,     lower alkyl, lower cycloalkyl, Het-lower alkyl or aryl, Het is a monocyclic 6-membered heteroaromatic radical containing one or two nitrogen atoms, which radical may be substituted by lower alkyl, halogen or aryl, and the asterisk denotes the point of attachment, when R₅ and R₆ are different, enantiomers and racemic mixtures thereof, when R₁ and R₂ are different, geometric isomers thereof, and pharmaceutically acceptable acid addition salts thereof. These compounds exhibit activity as platelet activating factor (PAF) antagonists and are, therefore, useful in disease states characterized by excess platelet activating factor or for the prevention and treatment of cardiovascular diseases, pulmonary diseases, immunological disorders, inflammatory diseases, dermatological disorders, shocks or transplant rejections.
    所述化合物通式如下 其中 Y 和 Y′为氢或合起来为 O 或 S,*A 为对苯二甲酸或 *-(CH₂)n-(X)s-(CH₂)r-,X 为 O、S 或-CH=CH-,n 和 r 独立地为 0 至 3 的整数,m 为 0 或 1 的整数、s 是 0 或 1 的整数,条件是当 s 为 1 时,n+m 至少为 2,t 是 0 至 10 的整数,R₁ 和 R₂ 独立地是低级烷基、低级烯基或芳基,或者 R₁ 和 R₂ 中的一个是氢,另一个是 W 是-CX₃=CX₄-、-CH₂-CH₂-、-CH₂-、O、S 或-NX₅-,X₁ 是低级烷基、苯基或带有最多 3 个选自低级烷氧基、低级烷基和卤素的取代基的苯基,X₂、X₃ 和 X₄ 独立地、是氢、低级烷基、低级烷氧基或卤素,X₅ 是低级烷基,R₃ 是氢、低级烷基或芳基,R₄ 是氢、低级烷基、芳基、芳基-低级烷基或酰基,R₅ 是氢或低级烷基,R₆ 是氢、 R₅是氢或低级烷基,R₆是氢、低级烷基、低级环烷基、Het-低级烷基或芳基,Het 是含有一个或两个氮原子的单环六元杂芳基,该基可被低级烷基、卤素或芳基取代,星号表示连接点、 当 R₅ 和 R₆ 不同时,其对映体和外消旋混合物;当 R₁ 和 R₂ 不同时,其几何异构体;以及其药学上可接受的酸加成盐。 这些化合物具有血小板活化因子(PAF)拮抗剂的活性,因此可用于以血小板活化因子过量为特征的疾病状态,或用于预防和治疗心血管疾病、肺部疾病、免疫性疾病、炎症性疾病、皮肤病、休克或移植排斥反应。
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