4-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-1,4-methanobenzo[4,5]imidazo[1,2-d][1,4]diazepin-8-yl)benzonitrile | 1272321-02-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-1,4-methanobenzo[4,5]imidazo[1,2-d][1,4]diazepin-8-yl)benzonitrile
• 英文别名: 4-(13-Cyclobutyl-2,9,13-triazatetracyclo[10.2.1.02,10.03,8]pentadeca-3(8),4,6,9-tetraen-6-yl)benzonitrile
• CAS: 1272321-02-4
• 化学式: C₂₃H₂₂N₄
• 分子量: 354.454
• InChiKey: NVVDIDLVNOXTHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  8-chloro-3-cyclobutyl-2,3,4,5-tetrahydro-1H-1,4-methanobenzo[4,5]imidazo[1,2-d][1,4]diazepine 、 4-氰基苯硼酸 在 palladium diacetate dicyclohexyl(3-dicyclohexylphosphaniumylpropyl)phosphonium ditetrafluoroborate 、 potassium fluoride dihydrate 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以31%的产率得到4-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-1,4-methanobenzo[4,5]imidazo[1,2-d][1,4]diazepin-8-yl)benzonitrile
  参考文献：
  名称：

  Histamine H3 Inverse Agonists and Antagonists and Methods of Use Thereof

  摘要：

  本文提供了融合咪唑基化合物，其合成方法以及使用方法。本文提供的化合物可用于治疗、预防和/或管理各种疾病，包括但不限于神经系统疾病和代谢性疾病。本文提供的化合物抑制组胺H3受体的活性，并调节各种神经递质的释放，例如组胺、乙酰胆碱、去甲肾上腺素和多巴胺（例如在突触处）。本文还提供了含有这些化合物的药物组合物及其使用方法。

  公开号：

  US20110065694A1

文献信息

• HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF
  申请人：Chytil Milan

  公开号：US20120172350A1

  公开（公告）日：2012-07-05

  Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

  本文提供了熔合咪唑基化合物、合成方法和使用方法。本文提供的化合物可用于治疗、预防和/或管理各种疾病，包括神经系统疾病和代谢性疾病等。本文提供的化合物抑制组胺H3受体的活性并调节多种神经递质的释放，例如组胺、乙酰胆碱、去甲肾上腺素和多巴胺（例如在突触处）。本文还提供了含有这些化合物的药物组合物和使用方法。
• [EN] HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF<br/>[FR] AGONISTES INVERSES ET ANTAGONISTES DU RÉCEPTEUR H3 DE L'HISTAMINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SEPRACOR INC

  公开号：WO2011031816A2

  公开（公告）日：2011-03-17

  Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.
• Histamine H3 Inverse Agonists and Antagonists and Methods of Use Thereof
  申请人：Chytil Milan

  公开号：US20110065694A1

  公开（公告）日：2011-03-17

  Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

  本文提供了融合咪唑基化合物，其合成方法以及使用方法。本文提供的化合物可用于治疗、预防和/或管理各种疾病，包括但不限于神经系统疾病和代谢性疾病。本文提供的化合物抑制组胺H3受体的活性，并调节各种神经递质的释放，例如组胺、乙酰胆碱、去甲肾上腺素和多巴胺（例如在突触处）。本文还提供了含有这些化合物的药物组合物及其使用方法。