sodium;4-ethylbenzenesulfinate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: sodium;4-ethylbenzenesulfinate
• 化学式: C8H9NaO2S
• 分子量: 192.21
• InChiKey: RHQNALOFSJPBIU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.51
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  59.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  sodium;4-ethylbenzenesulfinate 、 2-溴丙酸乙酯 、 氢氧化钾 、 氯化亚砜 生成 2-(4-ethylphenyl)sulfonylpropanoyl chloride
  参考文献：
  名称：

  OMOKAWA, HIROYOSHI;ICHIZEN, NOBUMASA;TABOGAMI, SHIGERU;TAKEMATSU, TETSUO, AGR. AND BIOL. CHEM., 1985, 49, N 12, 3551-3555

  摘要：

  DOI：
• 作为产物：
  描述：

  Disodium;sulfite 、 碳酸氢钠 、 4-乙基苯磺酰氯 在 水 作用下， 以 水 为溶剂， 反应 19.5h， 以to give 13.9 grams (>100% yield) of crude sodium 4-ethylbenzenesulfinate的产率得到sodium;4-ethylbenzenesulfinate
  参考文献：
  名称：

  5-Arylsulfonyl-imidazo[1',2':1,6]pyrido[2,3-b]pyrazine-6-amines and related compounds

  摘要：

  式1的化合物，其中a，X，R1，R2，R3和R4如上所定义，可用于治疗呼吸系统，过敏，风湿性，体重调节，炎症和中枢神经系统疾病，如哮喘，慢性阻塞性肺疾病，成人呼吸系统疾病综合征，休克，纤维化，肺过敏，过敏性鼻炎，特应性皮炎，银屑病，体重控制，风湿性关节炎，恶病质，克罗恩病，溃疡性结肠炎，关节炎和其他炎症性疾病，抑郁症，多发性梗塞性痴呆和艾滋病。

  公开号：

  US20030203911A1

文献信息

• [EN] 3-PHENYLSULPHONYL-QUINOLINE DERIVATIVES AS AGENTS FOR TREATING PATHOGENIC BLOOD VESSELS DISORDERS<br/>[FR] DÉRIVÉS DE 3-PHÉNYLSULFONYL-QUINOLÉINE EN TANT QU'AGENTS POUR LE TRAITEMENT DE TROUBLES DES VAISSEAUX SANGUINS PATHOGÈNES
  申请人：UNIV CALIFORNIA

  公开号：WO2021076886A1

  公开（公告）日：2021-04-22

  The disclosure provides compounds, and compositions, including pharmaceutical compositions, kits that include the compounds, and methods of using (or administering) and making the compounds. The disclosure further provides compounds or compositions thereof for use in a method of modulating PLXDC1 (TEM7) and/or PLXDC2 or killing pathogenic blood vessles. The disclosure further provides compounds or compositions thereof for use in a method of treating a disease, disorder, or condition that is mediated, at least in part, by PEDF receptors or by angiogenesis.

  该披露提供了化合物和组合物，包括药物组合物、包含这些化合物的试剂盒，以及使用（或给药）和制备这些化合物的方法。该披露进一步提供了用于调节PLXDC1（TEM7）和/或PLXDC2或杀灭病原性血管的方法中的化合物或其组合物。该披露还提供了用于治疗由PEDF受体或血管生成至少部分介导的疾病、紊乱或状况的方法中的化合物或其组合物。
• Acid- and radical-generating agent and method for generating acid and radical
  申请人：FUJIFILM Wako Pure Chemical Corporation

  公开号：US10451967B2

  公开（公告）日：2019-10-22

  It is a subject of the present invention to provide an acid- and radical-generating agent which has high sensitivity to an active energy ray having a wavelength of around 300 to 450 nm, and can exert both high acid-generating performance and high radical-generating performance, and has heat resistance; and a method for generating an acid and a radical. The present invention relates to a compound represented by the general formula (A); an acid- and radical-generating agent comprising the compound; and a method for generating an acid and a radical: wherein n pieces of R1 each independently represent an alkyl group, which may have a specific functional group in the chain, or in which a hydrogen atom may be substituted by a halogen atom; an alkoxy group, in which a hydrogen atom may be substituted by a halogen atom; an aryl group or an aryloxy group, in which a hydrogen atom may be substituted by a halogen atom, an alkyl group or a haloalkyl group; or an arylalkyl group or an arylalkyloxy group, in which a hydrogen atom may be substituted by a halogen atom, an alkyl group or a haloalkyl group; n pieces of R2 and R3 each independently represent a hydrogen atom, an alkyl group or an alkoxycarbonyl group; R4 to R7 each independently represent a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an alkenyl group, an aryl group, an alkoxycarbonyl group, a dialkylamino group or a nitro group; Y represents an oxygen atom, a sulfur atom, or a carbonyl group; n pieces of Z each independently represent a sulfonyl group or an alkoxyphosphoryl group; n represents 1 or 2.

  本发明的一个目的是提供一种对波长约为300至450纳米的活性能量射线具有高灵敏度的酸和自由基生成剂，能够发挥高酸生成性能和高自由基生成性能，并具有耐热性；以及一种生成酸和自由基的方法。本发明涉及一种由通式（A）表示的化合物；包括该化合物的酸和自由基生成剂；以及生成酸和自由基的方法：其中n个R1分别独立表示一种烷基基团，该烷基基团可能在链中具有特定的功能基团，或者氢原子可能被卤原子取代；一种烷氧基团，其中氢原子可能被卤原子取代；一种芳基或芳氧基，其中氢原子可能被卤原子，烷基或卤代烷基取代；或一种芳基烷基或芳基氧基，其中氢原子可能被卤原子，烷基或卤代烷基取代；n个R2和R3分别独立表示氢原子，烷基基团或烷氧羰基团；R4到R7分别独立表示氢原子，卤原子，烷基基团，烷氧基团，烯基基团，芳基，烷氧羰基团，二烷基氨基团或硝基；Y表示氧原子，硫原子或羰基；n个Z分别独立表示磺酰基或烷氧基磷酰基；n表示1或2。
• 5-arylsulfonyl-imidazo[1'2':1,6]pyrido[2,3-b]pyrazine-6-amines and related compounds
  申请人：——

  公开号：US20020013467A1

  公开（公告）日：2002-01-31

  A compound of the formula 1 wherein a, X, R 1 , R 2 , R 3 and R 4 are as defined above, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and central nervous system disorders such as asthma, chronic obstructive pulmonary disease, adult respiratory diseases syndrome, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS.

  一种化合物的公式为1，其中a，X，R1，R2，R3和R4如上所定义，可用于治疗呼吸系统、过敏、类风湿、体重调节、炎症和中枢神经系统紊乱，如哮喘、慢性阻塞性肺疾病、成人呼吸系统疾病综合征、休克、纤维化、肺过敏、过敏性鼻炎、特应性皮炎、银屑病、体重控制、类风湿性关节炎、消瘦、克罗恩病、溃疡性结肠炎、关节炎和其他炎症性疾病、抑郁症、多发性脑梗死和艾滋病。
• 5-arylsulfonyl-imidazo[1',2':1,6]pyrido[2,3-b]pyrazine-6-amines and related compounds
  申请人：——

  公开号：US20020147340A1

  公开（公告）日：2002-10-10

  A compound of the formula 1 wherein a, X, R 1 , R 2 , R 3 and R 4 are as defined above, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and central nervous system disorders such as asthma, chronic obstructive pulmonary disease, adult respiratory diseases syndrome, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS.

  化合物的公式1，其中a、X、R1、R2、R3和R4如上所定义，可用于治疗呼吸系统、过敏、风湿性、体重调节、炎症和中枢神经系统疾病，如哮喘、慢性阻塞性肺疾病、成人呼吸系统疾病综合征、休克、纤维化、肺过敏、过敏性鼻炎、特应性皮炎、银屑病、体重控制、风湿性关节炎、消瘦、克罗恩病、溃疡性结肠炎、关节炎和其他炎症性疾病、抑郁症、多发性梗塞性痴呆和艾滋病。
• 5-arylsulfonyl-imidazo&lsqb;1′,2′:1,6&rsqb;pyrido&lsqb;2,3-b&rsqb;pyrazine-6-amines and related compounds
  申请人：Pfizer Inc

  公开号：US06555538B2

  公开（公告）日：2003-04-29

  This application is directed to a compound of Formula I wherein a, X, R1, R2, R3 and R4 are as defined herein, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and central nervous system disorders such as asthma, chronic obstructive pulmonary disease, adult respiratory diseases syndrome, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, Crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS.

  本申请涉及一种公式I的化合物，其中a、X、R1、R2、R3和R4的定义如本文所述，可用于治疗呼吸系统、过敏性、类风湿性、体重调节、炎症和中枢神经系统疾病，如哮喘、慢性阻塞性肺疾病、成人呼吸系统疾病综合征、休克、纤维化、肺过敏、过敏性鼻炎、特应性皮炎、银屑病、体重控制、类风湿性关节炎、消瘦症、克罗恩病、溃疡性结肠炎、关节炎等其他炎症性疾病、抑郁症、多发性梗塞性痴呆和艾滋病。