1-Benzhydrylcyclohexan-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Benzhydrylcyclohexan-1-ol
• 化学式: C₁₉H₂₂O
• 分子量: 266.383
• InChiKey: GMPUTIVCBAOKBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  T406石油添加剂 、 二苯甲醇 、 环己酮 在 4-甲基苯磺酸吡啶 、 lithium 作用下， 生成 1-Benzhydrylcyclohexan-1-ol
  参考文献：
  名称：

  Transformations of N-Substituted Benzotriazoles into the Corresponding Carbanions by C−Benzotriazole Bond Scission

  摘要：

  Various N-substituted benzotriazoles are transformed, by scission of the C-benzotriazole bond, into the corresponding carbanions by treatment with lithium. Thus, N-(diphenylmethyl)benzotriazole (1), N-benzylbenzotriazole (6), and N-allylbenzotriazole (10) all gave carbanions that reacted with diverse electrophiles to afford the corresponding products in good yields. This new methodology was successfully utilized to convert N-benzylbenzotriazole (6) and N-allylbenzotriazole (10) into dianion synthons by a sequential lithiation and reductive coupling and bis(benzotriazolyl)toluene (18) by double reductive couplings, demonstrating the synthetic potential of the present methodology.

  DOI：

  10.1021/jo962246l

文献信息

• Dilithium diphenylmethanediide; generation, redox relationship with lithium chlorodiphenylmethanide, implication with regard to aggregation
  作者：Nicolaas J. R. van Eikema Hommes、Friedrich Bickelhaupt、Gerhard W. Klumpp

  DOI：10.1039/c39910000438

  日期：——

  Dilithium diphenylmethanediide, Ph2CLi2, prepared by reaction of dichlorodiphenylmethane with lithium p,p′-di-tert-butylbiphenyl, reacts with organic halides and carbonyl compounds to give lithium Chlorodiphenylmethanide, Ph2CLiCl, as a major product and is assumed to exist in two different states of aggregation.

  二锂diphenylmethanediide中，Ph 2 CLI 2，通过与锂dichlorodiphenylmethane的反应制备p，p ' -二-叔-butylbiphenyl，与有机卤化物和羰基化合物给予锂Chlorodiphenylmethanide，pH至发生反应2 CLiCl，作为主要产物，并假设存在两种不同的聚合状态。