1-(2-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]benzimidazol-5-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(2-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]benzimidazol-5-amine
• 化学式: C₂₂H₂₁N₃O₂
• 分子量: 359.4
• InChiKey: OKEQVACWLNFZTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  48.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION
  申请人：Siga Technologies, Inc.

  公开号：EP1988776B1

  公开（公告）日：2012-08-08
• Antiviral drugs for treatment of arenavirus infection
  申请人：Hruby E. Dennis

  公开号：US20070254934A1

  公开（公告）日：2007-11-01

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pichinde, and LCMV), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
• ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVRUS INFECTION
  申请人：Hruby Dennis E.

  公开号：US20080300265A1

  公开（公告）日：2008-12-04

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pichinde, and LCMV), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever and Crimean-Congo hemorrhagic fever).
• Anti-Viral Drugs for Treatment of Arenavirus Infection
  申请人：Hruby Dennis E.

  公开号：US20110172281A1

  公开（公告）日：2011-07-14

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pichinde, and LCMV), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
• Antiviral Drugs for Treatment of Arenavirus Infection
  申请人：Dai Dongcheng

  公开号：US20120071447A1

  公开（公告）日：2012-03-22

  Methods, compounds, and pharmaceutical compositions for treating an arenavirus infections are disclosed. Methods for preparing the compounds and pharmaceutical compositions are also disclosed. The novel compounds and compositions are used for treatment of an arenavirus infections, which include but are not limited to the following viruses: Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pichinde, and LCMV.