N-Aethyl-N'-(3-trifluormethyl-phenyl)-harnstoff | 783-06-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Aethyl-N'-(3-trifluormethyl-phenyl)-harnstoff
• 英文别名: 1-Ethyl-3-(3-trifluoromethyl-phenyl)-urea；1-ethyl-3-[3-(trifluoromethyl)phenyl]urea
• CAS: 783-06-2
• 化学式: C₁₀H₁₁F₃N₂O
• mdl: MFCD00032546
• 分子量: 232.205
• InChiKey: FGRDDASXWCZPIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间氨基三氟甲苯 、 异氰酸乙酯 生成 N-Aethyl-N'-(3-trifluormethyl-phenyl)-harnstoff
  参考文献：
  名称：

  Notes- Fluoro Analogs of Prostigmine

  摘要：

  DOI：

  10.1021/jo01081a625

文献信息

• Disaccharides for drug discovery
  申请人：Meutermans Wim

  公开号：US20110201794A1

  公开（公告）日：2011-08-18

  Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.

  本发明描述了制备可能具有生物活性的二糖化合物组合库的方法。这些化合物具有不同的官能团，旨在改变脂溶性，大小，功能和其他性质，特别是发现新型药物或类似药物的化合物，或具有有用性质的化合物。本发明提供了中间体、过程和合成策略，用于解决或固相合成不同官能团的二糖，包括芳香性和电荷的添加，以及药用有用基团和同分异构体的放置。
• Pyrazolopyrimidine derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating cancer, autoimmune disease and brain disease containing the same as an active ingredient
  申请人：Korea Research Institute of Chemical Technology

  公开号：US11084824B2

  公开（公告）日：2021-08-10

  The present invention relates to a pyrazolopyrimidine derivative, a preparation method thereof and a pharmaceutical composition comprising the same as an active ingredient for the prevention or treatment of cancer, autoimmune disease and brain disease. The pyrazolopyrimidine derivative of the present invention exhibits excellent Bruton's tyrosine kinase inhibition activity, so that it can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer, autoimmune disease and Parkinson's disease.

  本发明涉及一种吡唑嘧啶衍生物、其制备方法以及以其为活性成分的药物组合物，用于预防或治疗癌症、自身免疫性疾病和脑部疾病。本发明的吡唑嘧啶衍生物具有优异的布鲁顿酪氨酸激酶抑制活性，因此可以有效地用作预防或治疗癌症、自身免疫性疾病和帕金森病的药物组合物。
• PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
  申请人：Genentech, Inc.

  公开号：EP2318377B1

  公开（公告）日：2013-08-21
• IMIDAZOLONE COMPOUNDS AS HUMAN NEUTROPHIL ELASTASE INHIBITORS
  申请人：Chiesi Farmaceutici S.p.A.

  公开号：EP3464273B1

  公开（公告）日：2020-04-08
• PYRAZOLOPYRIMIDINE DERIVATIVES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTING OR TREATING CANCER, AUTOIMMUNE DISEASE AND BRAIN DISEASE CONTAINING THE SAME AS AN ACTIVE INGREDIENT
  申请人：Korea Research Institute of Chemical Technology

  公开号：US20200199129A1

  公开（公告）日：2020-06-25

  The present invention relates to a pyrazolopyrimidine derivative, a preparation method thereof and a pharmaceutical composition comprising the same as an active ingredient for the prevention or treatment of cancer, autoimmune disease and brain disease. The pyrazolopyrimidine derivative of the present invention exhibits excellent Bruton's tyrosine kinase inhibition activity, so that it can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer, autoimmune disease and Parkinson's disease.