4,7-dihydro-5-methyl-2-methylsulfonyl-7-oxo-1,2,4-triazolo[1,5-a]pyrimidine | 90000-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 英文名称: 4,7-dihydro-5-methyl-2-methylsulfonyl-7-oxo-1,2,4-triazolo[1,5-a]pyrimidine
• 英文别名: 4,7-Dihydro-6-methyl-3-methylsulfuryl-4-oxo-1,3,3a,7-tetraazainden；4,7-Dihydro-6-methyl-2-methylsulfuryl-4-oxo-1,3,3a,7-tetraazainden；2-methanesulfonyl-5-methyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one；5-Methyl-2-(methylsulfonyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol；5-methyl-2-methylsulfonyl-1H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
• CAS: 90000-59-2
• 化学式: C₇H₈N₄O₃S
• 分子量: 228.232
• InChiKey: MSIGCTXGGJXOQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  99.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙酰乙酸乙酯 、 5-甲基磺酰基-4H-1,2,4-三唑-3-胺 在 盐酸 、 四氯化锡 作用下， 以 various solvent(s) 为溶剂， 反应 6.0h， 以67%的产率得到4,7-dihydro-5-methyl-2-methylsulfonyl-7-oxo-1,2,4-triazolo[1,5-a]pyrimidine
  参考文献：
  名称：

  Tolstyakov; Pevzner; Tselinskii, Russian Journal of General Chemistry, 2000, vol. 70, # 9, p. 1458 - 1465

  摘要：

  DOI：

文献信息

• METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION
  申请人：Gross Benjamin

  公开号：US20100290987A1

  公开（公告）日：2010-11-18

  The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for identifying therapeutic compounds to treat glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention is also useful for identifying therapeutic compounds to treat de-glycosylation-associated disorders such as ischemic damage and traumatic injury. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins and also relates in part to compounds to treat glycosylation-associated diseases and disorders.
• US8524444B2
  申请人：——

  公开号：US8524444B2

  公开（公告）日：2013-09-03
• US8993718B2
  申请人：——

  公开号：US8993718B2

  公开（公告）日：2015-03-31
• [EN] METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION<br/>[FR] PROCÉDÉS ET COMPOSITIONS DE DÉTECTION ET DE MODULATION DE O-GLYCOSYLATION
  申请人：HARVARD COLLEGE

  公开号：WO2008156676A1

  公开（公告）日：2008-12-24

  [EN] The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for identifying therapeutic compounds to treat glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention is also useful for identifying therapeutic compounds to treat de-glycosylation-associated disorders such as ischemic damage and traumatic injury. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins and also relates in part to compounds to treat glycosylation-associated diseases and disorders.
  [FR] La présente invention concerne des procédés et des produits permettant de moduler la glycosylation de protéines. L'invention se révèle utile pour identifier des composés thérapeutiques destinés à traiter des troubles associés à la glycosylation, tels qu'une neurodégénérescence, le diabète, notamment les complications du diabète telles qu'une résistance à l'insuline, une néphropathie, une lésion microvasculaire et un dysfonctionnement endothélial. L'invention se révèle également utile pour identifier des composés thérapeutiques destinés à traiter des troubles associés à une déglycosylation, tels qu'une lésion ischémique et une lésion traumatique. L'invention concerne également partiellement des essais qui se révèlent utiles pour identifier et tester des composés candidats permettant de moduler la glycosylation de protéines et elle concerne également partiellement des composés destinés à traiter des maladies et des troubles associés à la glycosylation.
• Tolstyakov; Pevzner; Tselinskii, Russian Journal of General Chemistry, 2000, vol. 70, # 9, p. 1458 - 1465
  作者：Tolstyakov、Pevzner、Tselinskii

  DOI：——

  日期：——