2-(4-methylphenyl)methylimidazole | 793682-57-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-methylphenyl)methylimidazole
• 英文别名: 2-[(4-methylphenyl)methyl]-1H-imidazole
• CAS: 793682-57-2
• 化学式: C₁₁H₁₂N₂
• mdl: MFCD09908855
• 分子量: 172.23
• InChiKey: SBQBQLWYPUWSGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-[(4-甲基苯基)甲基]-4,5-二氢-1H-咪唑 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.83h， 以89%的产率得到2-(4-methylphenyl)methylimidazole
  参考文献：
  名称：

  A novel synthetic method for 2-arylmethyl substituted imidazolines and imidazoles from 2-aryl-1,1-dibromoethenes

  摘要：

  Various 2-arylmethylimidazolines were prepared by treating readily available 2-aryl-1, 1-dibromoethenes with ethylenediamine under mild conditions and further converted into the corresponding imidazoles smoothly with Swern oxidation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.08.035

文献信息

• Substituted imidazole and imidazoline derivatives and their preparation and use
  申请人：Farmos-Yhtyma Oy

  公开号：EP0064820A1

  公开（公告）日：1982-11-17

  The invention provides novel compounds of the formu- ' la: wherein each of R1, R2 and R3, which can be the same or different, is hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxy, amino, hydroxy or nitro; R4 and R5, which can be the same or different, are hydrogen, an alkyl radical of 1 to 7 carbon atoms, hydroxymethyl or R6 is hydrogen, an alkyl radical of 1 to 7 carbon atoms or R7 and R8 are hydrogen, chloro or methyl; X is-CH=CH- or CHR9; Rg is hydrogen or hydroxy; n is 0-7 and m is 0-6; and their non-toxic pharmaceutically acceptable acid addition salts and mixtures thereof. Processes for the preparation of these compounds are described, as are novel pharmaceutical compositions comprising at least one of the compounds and their salts. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are useful in the treatment of mammals, especially as antihypertensives and also as antithrombotic and antimycotic agents.

  本发明提供了如下形式的新型化合物： 其中 R1、R2 和 R3（可以相同或不同）分别为氢、氯、溴、氟、甲基、乙基、甲氧基、氨基、羟基或硝基；R4 和 R5（可以相同或不同）分别为氢、1 至 7 个碳原子的烷基、羟甲基或硝基。 R6 是氢、1 至 7 个碳原子的烷基或 R7和R8是氢、氯或甲基；X是-CH＝CH-或CHR9；Rg是氢或羟基；n是0-7，m是0-6；以及它们的无毒药学上可接受的酸加成盐及其混合物。本文描述了这些化合物的制备过程，以及包含至少一种化合物及其盐类的新型药物组合物。这些化合物及其无毒盐具有重要的药理活性，可用于哺乳动物的治疗，特别是作为抗高血压药以及抗血栓和抗霉菌药。
• A novel synthetic method for 2-arylmethyl substituted imidazolines and imidazoles from 2-aryl-1,1-dibromoethenes
  作者：Dal Ho Huh、Hoejin Ryu、Young Gyu Kim

  DOI：10.1016/j.tet.2004.08.035

  日期：2004.10

  Various 2-arylmethylimidazolines were prepared by treating readily available 2-aryl-1, 1-dibromoethenes with ethylenediamine under mild conditions and further converted into the corresponding imidazoles smoothly with Swern oxidation. (C) 2004 Elsevier Ltd. All rights reserved.