7-羟基香豆素硫酸盐 | 69526-88-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 7-羟基香豆素硫酸盐
• 中文别名: 2-氧代-2H-1-苯并吡喃-7-基-硫酸酯钾盐
• 英文名称: 7-Hydroxycoumarin sulfate
• 英文别名: 2H-1-Benzopyran-2-one, 7-(sulfooxy)-；(2-oxochromen-7-yl) hydrogen sulfate
• CAS: 69526-88-1
• 化学式: C₉H₆O₆S
• 分子量: 242.209
• InChiKey: LJOOSFYJELZGMR-UHFFFAOYSA-N

物化性质

• 熔点：
  204-205 °C
• 密度：
  1.692±0.06 g/cm3(Predicted)
• 溶解度：
  甲醇（微溶、加热、超声处理）、水（微溶、加热）

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98.3
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 危险品标志：
  Xn
• 危险类别码：
  R22
• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  7-羟基香豆素 在 吡啶 、 chlorosulphuric acid 作用下， 生成 7-羟基香豆素硫酸盐
  参考文献：
  名称：

  Studies in detoxication. 67. The biosynthesis of the glucuronides of umbelliferone and 4-methylumbelliferone and their use in fluorimetric determination of β-glucuronidase

  摘要：

  DOI：

  10.1042/bj0610569

文献信息

• METHODS OF TREATING CANCER WITH SMALL MOLECULE NF-kB INHIBITORS
  申请人：ImmuneTarget, Inc.

  公开号：US20190000851A1

  公开（公告）日：2019-01-03

  The present invention provides, inter alia, compounds capable of inhibiting NF-κB. Pharmaceutical compositions containing and methods of using the compounds are also provided herein. Also provided are methods and kits for treating cancer and solid tumors in a subject, as well as methods and kits for inducing cancer cell death and apoptosis of a cancer cell, all utilizing the NF-κB inhibitors described herein.

  本发明提供了一种能够抑制NF-κB的化合物，还提供了含有这些化合物的药物组合物以及使用这些化合物的方法。此外，还提供了用于治疗癌症和实体肿瘤的方法和试剂盒，以及利用本文描述的NF-κB抑制剂诱导癌细胞死亡和凋亡的方法和试剂盒。
• Novel Compositions and Methods of Treating Diseases Using the Same
  申请人：Roth Stephen

  公开号：US20120035161A1

  公开（公告）日：2012-02-09

  The invention includes compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, treating diseases associated with activated lymphocytes, or treating PAH.

  本发明涉及抑制活化淋巴细胞增殖和诱导凋亡的组合物和方法，用于治疗与活化淋巴细胞相关的疾病或治疗PAH。
• Cellular compositions and methods for their preparation
  申请人：Celsis In Vitro, Inc.

  公开号：EP2218777A1

  公开（公告）日：2010-08-18

  The present invention relates to cell (e.g., hepatocyte, etc.) compositions and methods for their preparation and use. In particular, the invention concerns methods of processing preparations of such cells so as to permit their repeated cryopreservation and thawing while retaining substantial viability. The invention also concerns preparations of cells (e.g., hepatocytes) that have been repeatedly cryopreserved and thawed.

  本发明涉及细胞（如肝细胞等）组合物及其制备和使用方法。特别是，本发明涉及处理此类细胞制剂的方法，以便在保留其大量活力的同时，允许其反复冷冻保存和解冻。本发明还涉及反复低温保存和解冻的细胞（如肝细胞）制剂。
• Stem cell-derived hepatocytes in co-culture and uses thereof
  申请人：Colorado State University Research Foundation

  公开号：US10266806B2

  公开（公告）日：2019-04-23

  The present disclosure provides co-cultures of human pluripotent stem cell derived hepatocytes and at least one non-parenchymal cell population in vitro, methods of preparing the co-cultures and methods of using the co-cultures for high throughput screening and evaluation of drug candidates. The stem cell derived hepatocyte co-culture system provides an in vitro model in which cell viability and relatively mature hepatocyte phenotype of stem cell derived hepatocytes are maintained for extended periods relative to conventional monoculture.

  本公开提供了体外人类多能干细胞衍生肝细胞和至少一种非亲本细胞群的共培养物、制备共培养物的方法以及使用共培养物进行候选药物高通量筛选和评估的方法。干细胞衍生肝细胞共培养系统提供了一种体外模型，与传统的单培养相比，干细胞衍生肝细胞的细胞活力和相对成熟的肝细胞表型可维持较长时间。
• Methods of treating cancer with small molecule NF-κB inhibitors
  申请人：ImmuneTarget, Inc.

  公开号：US11083729B2

  公开（公告）日：2021-08-10

  The present invention provides, inter alia, compounds capable of inhibiting NF-κB. Pharmaceutical compositions containing and methods of using the compounds are also provided herein. Also provided are methods and kits for treating cancer and solid tumors in a subject, as well as methods and kits for inducing cancer cell death and apoptosis of a cancer cell, all utilizing the NF-κB inhibitors described herein.

  本发明特别提供了能够抑制 NF-κB 的化合物。本发明还提供了含有这些化合物的药物组合物和使用这些化合物的方法。本发明还提供了用于治疗癌症和实体瘤的方法和试剂盒，以及用于诱导癌细胞死亡和癌细胞凋亡的方法和试剂盒，所有这些都利用了本文所述的 NF-κB 抑制剂。