GRI 519791 | 305859-72-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: GRI 519791
• 英文别名: 4-(amino-p-tolyl-methyl)phenol；4-(Amino(P-Tolyl)Methyl)Phenol；4-[amino-(4-methylphenyl)methyl]phenol
• CAS: 305859-72-7
• 化学式: C₁₄H₁₅NO
• 分子量: 213.279
• InChiKey: VBQFKQVMAVFLRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  GRI 519791 在 chiral stationary phase including isopropyl-functionalized CF₆ 作用下， 以 乙醇 、 正庚烷 、 三氟乙酸 为溶剂， 生成 4-[(R)-amino-(4-methylphenyl)methyl]phenol 、 4-[(S)-amino-(4-methylphenyl)methyl]phenol
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS
  [FR] COMPOSITIONS ET PROCÉDÉS POUR DES CYCLOFRUCTANES EN TANT QU'AGENTS DE SÉPARATION

  摘要：

  公开号：

  WO2010148191A3

文献信息

• Branched chain-containing aromatic compound
  申请人：AJINOMOTO CO., INC.

  公开号：US10711033B2

  公开（公告）日：2020-07-14

  The present invention provides a particular branched chain-containing aromatic compound. The branched chain-containing aromatic compound of the present invention is easily-soluble in isopropyl acetate superior in liquid-separation operability, and can be used for a production method of peptide and the like, which provides a final product simply by extraction separation, without crystallization and isolation of each intermediate in each step.

  本发明提供了一种特殊的含支链芳香族化合物。本发明的含支链芳香族化合物易溶于醋酸异丙酯，液体分离操作性好，可用于多肽等的生产方法，只需萃取分离即可得到最终产品，而无需在每个步骤中对每个中间体进行结晶和分离。
• COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS
  申请人：Board of Regents, The University of Texas System

  公开号：EP2443127A2

  公开（公告）日：2012-04-25
• US9175006B2
  申请人：——

  公开号：US9175006B2

  公开（公告）日：2015-11-03
• [EN] PROGRAMMABLE SELF-ASSEMBLED NANOSTRUCTURES BASED ON SIDECHAIN-MODIFIED PNA FOR THE MULTIVALENT DISPLAY OF LIGANDS<br/>[FR] NANOSTRUCTURES AUTO-ASSEMBLÉES PROGRAMMABLES BASÉES SUR UN APN À CHAÎNES LATÉRALES MODIFIÉES POUR LA PRÉSENTATION MULTIVALENTE DE LIGANDS
  申请人：USA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH & HUMAN SERVICES

  公开号：WO2011143323A2

  公开（公告）日：2011-11-17

  The invention concerns compositions comprising strands of polynucleotide and strands of PNA, each PNA strand comprising: (i) from 2 to 50 nucleobase subunits and (ii) one or more gamma substituents. The PNA strands are complementary to at least a portion of at least some of the polynucleotide strands, and the molar ratio of PNA strands to polynucleotide strands being at least 1:1. Certain gamma substituents are capable of effecting attachment of a PNA strand to a cell. The invention also concerns construction of nanostructure platforms and vaccines and use of the inventive compositions in inhibiting disease states in mammals.
• [EN] cGAP-PNA MULTIVALENT PEPTIDE NUCLEIC ACID LIGAND DISPLAY<br/>[FR] AFFICHAGE DE LIGAND ACIDE NUCLÉIQUE PEPTIDIQUE POLYVALENT CGAP-PNA
  申请人：US HEALTH

  公开号：WO2015112438A1

  公开（公告）日：2015-07-30

  Described herein are compositions composed of peptide nucleic acid strands. In some aspects the peptide nucleic acid strands are complementary to at least a portion of another peptide nucleic acid strand that may have one or more gamma substituents, where the ratio of PNA strands is least 1:1. Certain gamma substituents are capable of effecting attachment of a PNA strand to a cell. The disclosure also concerns construction of nanostructure platforms and vaccines and use of the inventive compositions in inhibiting disease states in mammals.