N-(3-carbamoyl-4,5-dimethylthiophen-2-yl)pyrazine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(3-carbamoyl-4,5-dimethylthiophen-2-yl)pyrazine-2-carboxamide
• 化学式: C₁₂H₁₂N₄O₂S
• 分子量: 276.32
• InChiKey: QPNCCIZEVYYMKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NOVEL INHIBITORS OF INSULIN-LIKE GROWTH FACTOR 2 MRNA BINDING PROTEINS
  申请人：Martin-Luther-Universität Halle-Wittenberg

  公开号：EP4008716A1

  公开（公告）日：2022-06-08

  The presented invention provides compounds of formula (I), or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein W, X, Y, Z, m, n and o are as defined herein. Said compounds of formula (I) are inhibitors of insulin-like growth factor 2 mRNA binding proteins (IGF2BP). Provided are novel inhibitors of IGF2BPs and processes for manufacturing the same. Efficacy of the new compounds is shown in solid cancer models.

  本发明提供了式 (I) 的化合物、 或其药学上可接受的盐、溶液或多晶型物，包括其所有同系物和立体异构体，其中 W、X、Y、Z、m、n 和 o 如本文所定义。所述式（I）化合物是胰岛素样生长因子 2 mRNA 结合蛋白（IGF2BP）的抑制剂。本文提供了新型 IGF2BPs 抑制剂及其生产工艺。在实体癌模型中显示了新化合物的功效。
• COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR
  申请人：RYDER Sean

  公开号：US20110065704A1

  公开（公告）日：2011-03-17

  The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.
• US8377639B2
  申请人：——

  公开号：US8377639B2

  公开（公告）日：2013-02-19
• US8962244B2
  申请人：——

  公开号：US8962244B2

  公开（公告）日：2015-02-24
• [EN] COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR<br/>[FR] COMPOSÉS DE MODULATION DES PROTÉINES DE LIAISON À L'ARN ET APPLICATIONS ASSOCIÉES
  申请人：UNIV MASSACHUSETTS

  公开号：WO2010151797A2

  公开（公告）日：2010-12-29

  The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.