4-(4-Nitro-phenyl)-valeriansaeure | 26232-95-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-Nitro-phenyl)-valeriansaeure
• 英文别名: γ-(p-Nitrophenyl)-valeriansaeure；4-(4-nitro-phenyl)-valeric acid；4-(4-Nitrophenyl)valeric acid；4-(4-nitrophenyl)pentanoic acid
• CAS: 26232-95-1
• 化学式: C₁₁H₁₃NO₄
• 分子量: 223.229
• InChiKey: KTQFCUQSXLZQMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(4-Nitro-phenyl)-valeriansaeure 以89%的产率得到
  参考文献：
  名称：

  DVALISHVILI A. I.; KLDIASHVILI R. SH.; VASHAKIDZE M. SH.; LAGIDZE R. M., IZV. AN GRUZ. CCP CEP. XIM., 1979, 5, HO 4, 360-362

  摘要：

  DOI：
• 作为产物：
  描述：

  4-苯基戊酸 在 硝酸 作用下， 生成 4-(4-Nitro-phenyl)-valeriansaeure
  参考文献：
  名称：

  Colonge; Fichet, Bulletin de la Societe Chimique de France, 1955, p. 412,414

  摘要：

  DOI：

文献信息

• Oxothienobenzoxepins, medicinal use, and process for the preparation
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04560701A1

  公开（公告）日：1985-12-24

  The invention relates to oxothienobenzoxepin compounds of the formula ##STR1## where X together with the carbon atoms to which it is attached is a thiophene ring; R.sub.1 is hydrogen, a straight or branched chain alkyl group having 1 to 5 carbon atoms or a halogen atom; R.sub.2 is hydrogen or a straight chain alkyl group having 1 to 5 carbon atoms; and R.sub.3 is hydroxyl or ##STR2## where R.sub.4 is a straight chain or branched chain alkyl group having 1 to 10 carbon atoms, a phenyl group or a trifluoromethyl group. Methods for preparing the compounds and their use as antiinflammatory and analgesic agents are provided.

  该发明涉及公式为##STR1##的氧硫杂噁苯并氧杂蒽啉化合物，其中X与其连接的碳原子一起是噻吩环；R.sub.1是氢、具有1至5个碳原子的直链或支链烷基基团或卤原子；R.sub.2是氢或具有1至5个碳原子的直链烷基基团；R.sub.3是羟基或##STR2##，其中R.sub.4是具有1至10个碳原子的直链或支链烷基基团、苯基或三氟甲基基团。提供了制备这些化合物以及它们作为抗炎和镇痛剂的用途的方法。
• (6,11-dihydro-11-oxodibenz[b,e]oxepin-yl)pentanoic acids and derivatives
  申请人：Hoechst-Roussel Pharmaceuticals, Inc.

  公开号：US05008285A1

  公开（公告）日：1991-04-16

  Novel (6,11-dihydro-11-oxodibenz[b,e]oxepinyl)pentanoic acids and derivatives thereof, intermediates and processes for the preparation thereof, and methods for suppressing arthritis-like inflammation utilizing compounds or compositions thereof are disclosed.

  本发明揭示了(6,11-二氢-11-氧代二苯并[b,e]氧杂环戊酸)及其衍生物、中间体、制备方法，并揭示了利用该化合物或其组合物抑制类风湿性关节炎炎症的方法。
• Substituted 4,10-dihydro-10-oxothieno benzoxepins, a method of preparing the same and intermediate thereof and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0118867A2

  公开（公告）日：1984-09-19

  There are described substituted 4,10-dihydro-10-oxothienobenzoxepins of the formula wherein R is hydrogen, loweralkyl, or -CH2CH(OH)CH2OH; R1 is hydrogen or loweralkyl; and R2 is hydrogen or loweralkyl, which are useful as anti-inflammatory and analgetic agents, intermediate compounds therefor, and a method of preparing the same.

  描述了式中 R 为氢、低级烷基或-CH2CH(OH)CH2OH；R1 为氢或低级烷基；R2 为氢或低级烷基的取代的 4,10-二氢-10-氧代噻吩并氧杂环庚烷，它们可用作消炎和镇痛剂、其中间化合物以及制备方法。
• (6,11-Dihydro-11-oxodibenz(b,e)oxepinyl)pentanoic acids and derivatives, a process and intermediates for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0159684A2

  公开（公告）日：1985-10-30

  Novel (6,11-dihydro-11-oxodibenz[b,e]oxepinyl)pentanoic acids and derivatives thereof, intermediates and processes for the preparation thereof, and their use for suppressing arthritis-like inflammation are disclosed.

  本发明公开了新型（6,11-二氢-11-氧代二苯并[b,e]氧杂卓基）戊酸及其衍生物、中间体和制备工艺，以及它们在抑制关节炎样炎症方面的用途。
• LAGIDZE D. R.; TALAKVADZE L. YA.; REVAZISHVILI T. N.; TSULUKIDZE L. A.; L+, IZV. AN GRUZSSR CEP. XIM., 1980, HO 3, 225-231
  作者：LAGIDZE D. R.、 TALAKVADZE L. YA.、 REVAZISHVILI T. N.、 TSULUKIDZE L. A.、 L+

  DOI：——

  日期：——