(-)-(1S,2R)-2-fluorocyclopentan-1-aminium chloride | 932706-27-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: (-)-(1S,2R)-2-fluorocyclopentan-1-aminium chloride
• 英文别名: (1S,2R)-2-fluorocyclopentylamine hydrochloride；(1S,2R)-2-Fluorocyclopentan-1-amine hydrochloride；(1S,2R)-2-fluorocyclopentan-1-amine;hydrochloride
• CAS: 932706-27-9
• 化学式: C₅H₁₀FN*ClH
• 分子量: 139.6
• InChiKey: ZJXOEOALNHXCOE-JBUOLDKXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.26
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ((1R,2S)-2-fluorocyclopentyl)isoindolyl-1,3-dione 在 盐酸 作用下， 以 水 为溶剂， 反应 5.0h， 生成 (-)-(1S,2R)-2-fluorocyclopentan-1-aminium chloride
  参考文献：
  名称：

  Synthesis of optically active vicinal fluorocyclopentanols and fluorocyclopentanamines by enzymatic deracemization

  摘要：

  DOI：

  10.24820/ark.5550190.p011.634

文献信息

• Aryl-Substituted Nitrogen-Containing Heterocyclic Compounds
  申请人：Ito Hirokatsu

  公开号：US20090275617A1

  公开（公告）日：2009-11-05

  Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I) [in the formula, A 1 , A 2 and A 3 independently represent a carbon atom or a nitrogen atom, and one or two of A 1 , A 2 and A 3 represent a carbon atom; R 1 represents a lower alkyl group or the like; R 2 represents a phenyl group which may be substituted with a halogen atom or the like; R 3 represents a hydrogen atom, a lower alkyl group or the like; and R 4 represents a lower alkyl group or the like.]

  本发明公开了一种芳基取代的含氮杂环化合物，其化学式如下（I），或其药学上可接受的盐。该化合物作为伤害感受受体拮抗剂，并且可用作治疗与伤害感受受体相关的疾病的药物。 （I）[在该式中，A1，A2和A3独立地表示碳原子或氮原子，其中一个或两个A1，A2和A3表示碳原子；R1表示较低的烷基或类似物；R2表示苯基，其可以用卤素原子或类似物取代；R3表示氢原子，较低的烷基或类似物；R4表示较低的烷基或类似物。]
• ARYL-SUBSTITUTED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1935881A1

  公开（公告）日：2008-06-25

  Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I) [in the formula, A1, A2 and A3 independently represent a carbon atom or a nitrogen atom, and one or two of A1, A2 and A3 represent a carbon atom; R1 represents a lower alkyl group or the like; R2 represents a phenyl group which may be substituted with a halogen atom or the like; R3 represents a hydrogen atom, a lower alkyl group or the like; and R4 represents a lower alkyl group or the like.]

  本发明公开了由下式(I)代表的芳基取代的含氮杂环化合物或其药学上可接受的盐。该化合物可作为痛觉素受体拮抗剂，可用于治疗与痛觉素受体相关的疾病。(I) [式中，A1、A2 和 A3 分别代表碳原子或氮原子，A1、A2 和 A3 中的一个或两个代表碳原子；R1 代表低级烷基或类似基团；R2 代表可被卤素原子或类似基团取代的苯基；R3 代表氢原子、低级烷基或类似基团；R4 代表低级烷基或类似基团。］
• WO2007/37513
  申请人：——

  公开号：——

  公开（公告）日：——
• US7829586B2
  申请人：——

  公开号：US7829586B2

  公开（公告）日：2010-11-09
• Synthesis of optically active vicinal fluorocyclopentanols and fluorocyclopentanamines by enzymatic deracemization
  作者：Olga O. Kolodiazhna、Dmitry V. Prysiazhnuk、Anastasy O. Kolodiazhna、Oleg I. Kolodiazhnyi

  DOI：10.24820/ark.5550190.p011.634

  日期：——