(E)-1-tert-butyl 5-methyl 4-(3-chlorobenzylidene)-2-(diphenylmethyleneamino)pentanedioate | 1149760-08-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-tert-butyl 5-methyl 4-(3-chlorobenzylidene)-2-(diphenylmethyleneamino)pentanedioate
• 英文别名: 5-O-tert-butyl 1-O-methyl (2E,4S)-4-(benzhydrylideneamino)-2-[(3-chlorophenyl)methylidene]pentanedioate
• CAS: 1149760-08-6
• 化学式: C₃₀H₃₀ClNO₄
• 分子量: 504.026
• InChiKey: CUYSSBKJPNKYFN-INZJWMLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  65
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-二苯亚甲基-甘氨酸叔丁酯 、 methyl 2-(acetoxy-(3-chlorophenyl)methyl)acrylate 在 tetrakis(acetonitrile)copper(I) perchlorate 、 1-[4(S)-tert-butyl-2-oxazolin-2-yl]-2(S)-(diphenylphosphino)ferrocene 、 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 以99%的产率得到(E)-1-tert-butyl 5-methyl 4-(3-chlorobenzylidene)-2-(diphenylmethyleneamino)pentanedioate
  参考文献：
  名称：

  Highly Enantioselective Cu-Catalyzed Conjugate Addition−Elimination of Activated Allylic Acetates with Glycine Derivatives

  摘要：

  The reaction of a glycinate Schiff base with the activated alkyl- and aryl-substituted allylic acetates afforded 4-alkylidenylglutamic acid derivatives in high yields and high enantioselectivities by using Cu/P,N-FcPhox as the catalyst.

  DOI：

  10.1021/ol900439h

文献信息

• Highly Enantioselective Cu-Catalyzed Conjugate Addition−Elimination of Activated Allylic Acetates with Glycine Derivatives
  作者：Chun-Gen Chen、Xue-Long Hou、Lin Pu

  DOI：10.1021/ol900439h

  日期：2009.5.21

  The reaction of a glycinate Schiff base with the activated alkyl- and aryl-substituted allylic acetates afforded 4-alkylidenylglutamic acid derivatives in high yields and high enantioselectivities by using Cu/P,N-FcPhox as the catalyst.