Regiospecific bromination-rearrangement of the 5-substituted 2-alkylidene-4-oxothiazolidine derivatives induced by pyridinium hydrobromide perbromide (PHBP) provides a new synthetic approach to the corresponding push-pullthiazolidines with two exocyclic double bonds. In comparison to a heterogenous alternative, this conversion, taking place in acetonitrile under homogenous reaction conditions, has
由过
溴氢溴酸吡啶 (
PHBP) 诱导的 5-取代的 2-亚烷基-4-氧代
噻唑烷衍
生物的区域特异性
溴化重排为具有两个环外双键的相应推拉
噻唑烷提供了一种新的合成方法。与非均相替代方案相比,这种转化在均相反应条件下在
乙腈中发生,具有几乎定量产率和显着提高速率的优点。