Compound having tgfß inhibitory activity and medicinal composition containing the same
申请人:Shimizu Kiyoshi
公开号:US20060111375A1
公开(公告)日:2006-05-25
The present invention provides compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof:
wherein X represents CH or N; Z represents —O—, —NH— or —C(═O)—; R and R′ represent a hydrogen atom, hydroxyl, a halogen atom, optionally substituted alkyl, optionally substituted alkenyl optionally substituted alkoxy, amino, aminocarbonyl, or an optionally substituted heterocyclic group; and A represents an optionally substituted specific carbocyclic or heterocyclic group. The compounds according to the present invention have excellent TGFβ inhibitory activity.
The invention relates to 6-piperidinyl-substituted isoquinoline derivatives of the formula (I)
useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
COMPOUND HAVING TGFBETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
申请人:Shimizu Kiyoshi
公开号:US20090312313A1
公开(公告)日:2009-12-17
The present invention provides compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof:
wherein X represents CH or N; Z represents —O—, —NH— or —C(═O)—; R and R′ represent a hydrogen atom, hydroxyl, a halogen atom, optionally substituted alkyl, optionally substituted alkenyl optionally substituted alkoxy, amino, aminocarbonyl, or an optionally substituted heterocyclic group; and A represents an optionally substituted specific carbocyclic or heterocyclic group. The compounds according to the present invention have excellent TGFβ inhibitory activity.
The invention relates to 6-piperidinyl-substituted isoquinoline derivatives of the formula (I)
useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
The invention relates to 6-piperidinyl-substituted isoquinoline derivatives of the formula (I)
useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.