N-(6,7,8,9-Tetrahydro-5H-benzocyclohepten-5-yl)-acetamide | 35047-91-7

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: N-(6,7,8,9-Tetrahydro-5H-benzocyclohepten-5-yl)-acetamide
• 英文别名: 5-Acetamido-6,7,8,9-tetrahydro-5H-benzocycloheptene；N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl)acetamide
• CAS: 35047-91-7
• 化学式: C₁₃H₁₇NO
• mdl: MFCD01671163
• 分子量: 203.284
• InChiKey: VIOBOLPVFXWEHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(6,7,8,9-Tetrahydro-5H-benzocyclohepten-5-yl)-acetamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 Diethyl-(6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl)-amine
  参考文献：
  名称：

  Vejdelek,Z.J.; Protiva,M., Collection of Czechoslovak Chemical Communications, 1971, vol. 36, p. 1611 - 1623

  摘要：

  DOI：

文献信息

• [EN] INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 AND METHODS OF USE<br/>[FR] INHIBITEURS DE L'INTÉGRINE ALPHA 2 BÊTA 1 ET PROCÉDÉS D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2019178248A1

  公开（公告）日：2019-09-19

  Disclosed herein, inter alia, are inhibitors of integrin alpha 2 beta 1 and methods of using the same.

  本文披露了抑制整合素α2β1的方法，以及使用这些方法的方法。
• Therapeutic compounds and uses thereof
  申请人：GENENTECH, INC.

  公开号：US10258603B2

  公开（公告）日：2019-04-16

  The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, Rc, and Rd have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.

  本发明涉及式（I）化合物： 及其盐，其中 R1、R2、Rc 和 Rd 具有说明书中定义的任意值，以及其组合物和用途。这些化合物可用作溴链的抑制剂。还包括包含式(I)化合物或其药学上可接受的盐的药物组合物，以及使用这种化合物和盐治疗各种溴链介导的疾病的方法。
• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：GENENTECH, INC.

  公开号：US20170340604A1

  公开（公告）日：2017-11-30

  The present invention relates to compounds of formula (I): and to salts thereof, wherein R 1 , R 2 , R c , and R d have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
• INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 AND METHODS OF USE
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20210387986A1

  公开（公告）日：2021-12-16

  Disclosed herein, inter alia, are inhibitors of integrin alpha 2 beta 1 and methods of using the same.
• Vejdelek,Z.J.; Protiva,M., Collection of Czechoslovak Chemical Communications, 1971, vol. 36, p. 1611 - 1623
  作者：Vejdelek,Z.J.、Protiva,M.

  DOI：——

  日期：——