[(4-Amino-phenyl)-hydroxy-phosphinoylmethyl]-phosphonic acid | 344585-75-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(4-Amino-phenyl)-hydroxy-phosphinoylmethyl]-phosphonic acid
• 英文别名: {[(4-Aminophenyl)(hydroxy)phosphoryl]methyl}phosphonic acid；[(4-aminophenyl)-hydroxyphosphoryl]methylphosphonic acid
• CAS: 344585-75-7
• 化学式: C₇H₁₁NO₅P₂
• 分子量: 251.116
• InChiKey: FJMOTJVSIZNBEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-fluoro-6-chloro-9-cyclopentylpurine 、 [(4-Amino-phenyl)-hydroxy-phosphinoylmethyl]-phosphonic acid 在 N,N-二异丙基乙胺 作用下， 以 二甲基亚砜 为溶剂， 生成
  参考文献：
  名称：

  Bone-Targeted 2,6,9-Trisubstituted purines: novel inhibitors of Src tyrosine kinase for the treatment of bone diseases

  摘要：

  Novel bone-targeted 2,6,9-trisubstituted purine template-based inhibitors of Src tyrosine kinase are described. Drug design studies of known purine compounds revealed that both positions-2 and -6 were suitable for incorporating bone-seeking moieties. A variety of bone-targeting groups with different affinity to hydroxyapatite were utilized in the study. Compound 3d was determined to be a potent Src inhibitor and was quite selective against a panel of other protein kinases. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00648-6

文献信息

• Purine derivatives
  申请人：——

  公开号：US20020068721A1

  公开（公告）日：2002-06-06

  This invention relates to compounds of the general formula: 1 in which R A , R B , R C and R D are as defined herein, and to their preparation and use.

  本发明涉及一般式为1的化合物，其中RA、RB、RC和RD的定义如本文所述，以及它们的制备和使用。
• [EN] PURINE DERIVATIVES<br/>[FR] DERIVES DE LA PURINE
  申请人：ARIAD PHARMA INC

  公开号：WO2001044259A1

  公开（公告）日：2001-06-21

  This invention relates to compounds of general formula (I) in which R?A, RB, RC and RD¿ are as defined herein, and to their preparation and use.

  本发明涉及一般式（I）的化合物，其中R？A，RB，RC和RD¿如本文所定义，以及它们的制备和使用。
• Novel perines
  申请人：Metcalf A. Chester

  公开号：US20050096298A1

  公开（公告）日：2005-05-05

  Novel purines and uses of these compounds for the treatment of bone related disorders and cancer is disclosed.

  本发明揭示了新型嘌呤类化合物及其用于治疗与骨相关的疾病和癌症的用途。
• Novel purinse
  申请人：——

  公开号：US20020132819A1

  公开（公告）日：2002-09-19

  Novel purines and uses of these compounds for the treatment of bone related disorders and cancer is disclosed.

  本发明公开了新型嘌呤类化合物及其在治疗与骨相关的疾病和癌症方面的应用。
• PURINE DERIVATIVES
  申请人：ARIAD PHARMACEUTICALS, INC.

  公开号：EP1244679A1

  公开（公告）日：2002-10-02