N-cyclohexyl-3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-cyclohexyl-3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionamide
• 英文别名: N-cyclohexyl-3-(2-methoxyphenyl)-3-[4-(propan-2-yloxy)phenyl]propanamide；N-cyclohexyl-3-(2-methoxyphenyl)-3-(4-propan-2-yloxyphenyl)propanamide
• 化学式: C₂₅H₃₃NO₃
• 分子量: 395.542
• InChiKey: HCSOQNNBXMYAHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(4-Isopropoxyphenyl)-3-(2-methoxyphenyl)propionitrile 在 氯化亚砜 、 三乙胺 、 potassium hydroxide 作用下， 以 苯 为溶剂， 反应 11.0h， 生成 N-cyclohexyl-3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionamide
  参考文献：
  名称：

  Synthesis of 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionamides

  摘要：

  Hydrolysis of 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionitrile results in 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionic acid, which after reaction with thionyl chloride is turned into acylchloride. By acylation of a number of amines by 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionyl chloride, synthesized the corresponding propionamides. The results of biological tests showed that the obtained compounds possess week antibacterial activity.

  DOI：

  10.1134/s1070363214110073

文献信息

• Synthesis of 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionamides
  作者：N. S. Arutyunyan、O. A. Papoyan、L. A. Akopyan、R. V. Paronikyan、G. A. Panosyan、G. A. Gevorgyan

  DOI：10.1134/s1070363214110073

  日期：2014.11

  Hydrolysis of 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionitrile results in 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionic acid, which after reaction with thionyl chloride is turned into acylchloride. By acylation of a number of amines by 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionyl chloride, synthesized the corresponding propionamides. The results of biological tests showed that the obtained compounds possess week antibacterial activity.