2,2'-Dimethyl-5,5'-bis-benzymidazolyl | 1155-27-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2,2'-Dimethyl-5,5'-bis-benzymidazolyl
• 英文别名: 2,2'-Dimethyl-bis-benzimidazolyl-(5,5'), 2,2'-Dimethyl-5,5'-di-(benzimidazol)；2,2'-Dimethyl-bis-benzimidazolyl-(5,5')；2,2'-dimethyl-1(3)H,1'(3')H-[5,5']bibenzoimidazolyl；2-methyl-6-(2-methyl-3H-benzimidazol-5-yl)-1H-benzimidazole
• CAS: 1155-27-7
• 化学式: C₁₆H₁₄N₄
• 分子量: 262.314
• InChiKey: QLFKSDSHYQVWNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  57.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,3'-二氨基联苯胺 、 乙酰氯 在 potassium fluoride on basic alumina 、 magnesium sulfate 作用下， 以 乙腈 为溶剂， 反应 1.5h， 以71%的产率得到2,2'-Dimethyl-5,5'-bis-benzymidazolyl
  参考文献：
  名称：

  KF / Al 2 O 3：室温下一锅合成苯并咪唑和双苯并咪唑的高效固体多相碱催化剂

  摘要：

  摘要KF / Al 2 O 3是一种有效的固体非均相碱催化剂，可用于由1,2-苯二胺或3,3'-二氨基联苯胺和酰氯一锅法合成2-取代的苯并咪唑和2,2'-二取代的双-苯并咪唑，酸酐和酯在室温下。 图形概要

  DOI：

  10.1007/s00706-011-0647-7

文献信息

• Benzimidazole, Benzoxazole and Benzothiazole Derivatives, Optical Film Comprising them and Method of Producing thereof
  申请人：Nokel Alexey

  公开号：US20100279122A1

  公开（公告）日：2010-11-04

  The present invention is relates to the synthesis of predominantly planar heterocyclic organic compound and the manufacture of optical films based on these compounds. Said organic compound has the general structural formula where Het is a predominantly planar heterocyclic molecular system possessing hydrophilic properties; B is a binding group; p is the number in the range from 3 to 8; S is a group providing solubility of the organic compound; m is a number in the range from 0 to 8. Said organic compound is transparent for electromagnetic radiation in the visible spectral range from 400 to 700 nm, and a solution of the compound or a salt thereof is capable of forming a substantially transparent optical layer on a substrate, with the heterocyclic molecular planes oriented predominantly parallel to the substrate surface.

  本发明涉及主要呈平面状的杂环有机化合物的合成以及基于这些化合物的光学薄膜的制造。所述有机化合物具有通用结构公式，其中Het是一个主要呈平面状的具有亲水性质的杂环分子体系；B是一个结合基团；p是一个3到8之间的数；S是一个提供有机化合物溶解度的基团；m是一个0到8之间的数。所述有机化合物对可见光谱范围内400到700纳米的电磁辐射是透明的，并且该化合物或其盐的溶液能够在基底上形成基本透明的光学层，其中杂环分子平面主要平行于基底表面。
• Reaction of 1,3-dicarbonyl compounds with<i>o</i>-phenylenediamine or 3,3′-diaminobenzidine in water or under solvent-free conditions via microwave irradiation
  作者：Zhong-Xia Wang、Hua-Li Qin

  DOI：10.1002/jhet.5570420540

  日期：2005.7

  Reaction of ophenylenediamine with β-diketones or β-ketoesters in water formed 2-substituted benzimi-dazoles. Reaction of 3,3′-diaminobenzidine gave similar results. Under microwave irradiation conditions solvent-free reaction of o-phenylenediamine with β-ketoesters afforded l,5-benzodiazepin-2-one derivatives. An exception is the reaction of o-phenylenediamine with ethyl acetoacetate under microwave

  邻苯二胺与β-二酮或β-酮酸酯在水中的反应形成2-取代的苯并咪唑。3，3′-二氨基联苯胺的反应得到相似的结果。在微波辐射条件下，邻苯二胺与β-酮酸酯的无溶剂反应得到1，5-苯并二氮杂-2-酮衍生物。例外是邻苯二胺与乙酰乙酸乙酯在微波辐射下反应，得到2-甲基苯并咪唑。
• HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES
  申请人：Zhi Lin

  公开号：US20120295904A1

  公开（公告）日：2012-11-22

  The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.

  本实施例涉及具有生理效应的化合物，例如激活造血生长因子受体。本实施例还涉及使用这些化合物来治疗各种状况、疾病和疾病，例如造血系统状况和疾病。
• SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
  申请人：Panicker Bijoy

  公开号：US20110237633A1

  公开（公告）日：2011-09-29

  The present invention provides compounds and pharmaceutically acceptable compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which hepatocyte growth factor/scatter factor (HGF/SF) or the activities thereof, or agonists or antagonists thereof, have a therapeutically useful role.

  本发明提供化合物及其药学上可接受的组合物，以及使用它们治疗一系列疾病或病症的方法，其中包括肝细胞生长因子/散发因子（HGF/SF）或其活性，或其激动剂或拮抗剂在治疗中具有治疗作用。
• USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS
  申请人：Bissonnette Reid P.

  公开号：US20140243324A1

  公开（公告）日：2014-08-28

  The present invention relates to uses of small molecule mimetics of hematopoietic growth factors. In particular the present invention relates to uses of small molecule mimetics of erythropoietin.

  本发明涉及使用小分子模拟血液生成生长因子的用途。特别是本发明涉及使用小分子模拟红细胞生成素的用途。