menisperine iodide | 17669-18-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 阿朴菲
• 英文名称: menisperine iodide
• 英文别名: N-methylisocorydine iodide；11-hydroxy-1,2,10-trimethoxy-6,6-dimethyl-6aα-aporphanium; iodide；11-Hydroxy-1,2,10-trimethoxy-6,6-dimethyl-6aα-aporphanium; Jodid；(6aS)-1,2,10-trimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-11-olate;hydroiodide
• CAS: 17669-18-0
• 化学式: C₂₁H₂₆NO₄*I
• 分子量: 483.346
• InChiKey: HPIWMGFECDATDK-UQKRIMTDSA-N

物化性质

• 熔点：
  225-226 °C (decomp)(Solv: methanol (67-56-1); water (7732-18-5))

计算性质

• 辛醇/水分配系数(LogP)：
  0.32
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  异紫堇定碱 、 碘甲烷 以 丙酮 为溶剂， 以5 mg的产率得到menisperine iodide
  参考文献：
  名称：

  Aporphine and bisaporphine alkaloids from Aristolochia lagesiana var. intermedia

  摘要：

  Corydines, isocorydines, and analogous aporphine alkaloids were isolated from the leaves of Aristolochia lagesiana var intermedia, together with three bisaporphine salts (lagesianines B-D) Their structures were determined by chemical derivatizations and spectroscopic analyses Lagesianines B and C are the first examples of N-CH(2)-N' and C-2-O-C-1' linked dimeric aporphine alkaloids, respectively, while the monomeric units of lagesianine D. which has a carbon skeleton, are linked through C-7-C-5' via ail ethane-1,2-diol group (C-7-CHOHCHOH-C-5') (C) 2009 Elsevier Ltd. All rights reserved

  DOI：

  10.1016/j.phytochem.2009.11.010

文献信息

• Neue Alkaloide aus<i>Peumus boldus</i>M<scp>OLINA</scp>
  作者：A. Rüegger

  DOI：10.1002/hlca.19590420317

  日期：——

  isoliert wcrden. Isocorydin und N-Methyllaurotetanin sind schon früher in anderen Pflanzen aufgefunden worden; Nor-isocorydin, dessen Konstitution durch Umwandlung in Isocorydin festgelegt wurde, ist ein neues Alkaloid.

  除博尔丁外，还可以从大黑杨（Peumus boldus MOLINA）的叶子中分离出海豚碱生物碱异ocoryrydin，去甲异丁烯酸和N-甲基月桂鞣质。在其他植物中较早地发现了异豆蔻丁和N-甲基十二烷基芦丁。正异二十二烯酸是一种新的生物碱，其组成是通过将其转化为异十八碳素而确定的。
• Aporphine and bisaporphine alkaloids from Aristolochia lagesiana var. intermedia
  作者：Marcia L.R. Ferreira、Inara C. de Pascoli、Isabele R. Nascimento、Julio Zukerman-Schpector、Lucia M.X. Lopes

  DOI：10.1016/j.phytochem.2009.11.010

  日期：2010.3

  Corydines, isocorydines, and analogous aporphine alkaloids were isolated from the leaves of Aristolochia lagesiana var intermedia, together with three bisaporphine salts (lagesianines B-D) Their structures were determined by chemical derivatizations and spectroscopic analyses Lagesianines B and C are the first examples of N-CH(2)-N' and C-2-O-C-1' linked dimeric aporphine alkaloids, respectively, while the monomeric units of lagesianine D. which has a carbon skeleton, are linked through C-7-C-5' via ail ethane-1,2-diol group (C-7-CHOHCHOH-C-5') (C) 2009 Elsevier Ltd. All rights reserved