2-amino-4-tosyl-5-chloro-1,3-thiazole | 153941-62-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-4-tosyl-5-chloro-1,3-thiazole
• 英文别名: 2-Thiazolamine, 5-chloro-4-[(4-methylphenyl)sulfonyl]-；5-chloro-4-(4-methylphenyl)sulfonyl-1,3-thiazol-2-amine
• CAS: 153941-62-9
• 化学式: C₁₀H₉ClN₂O₂S₂
• 分子量: 288.779
• InChiKey: OASFRGZUWKBTMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 2-amino-4-tosyl-5-chloro-1,3-thiazole 反应 1.0h， 以83%的产率得到2-acetylamino-4-tosyl-5-chloro-1,3-thiazole
  参考文献：
  名称：

  摘要：

  A series of 2-X-4-tosyl-5-chloro-1,3-thiazoles (X = OH, OAlk, SH, SAlk, NH2, NHAlk, NAlk(2), NHAr, etc.) were prepared from accessible 1-tosyl-2,2-dichloroethenyl isothiocyanate. only some of these compounds containing a moderately labile hydrogen atom peculiarly react with thiophenols in the presence of triethylamine to give 4,5-di(arylthio)-2-(hydroxy- or arylamino)-1,3-thiazoles, which are difficult to prepare by other routes. It is quite possible that, in the course of nucleophilic substitution of the chlorine atom and tosyl residue by the corresponding arylthio groups, a significant role is played by nonaromatic tautomeric forms of functionally 2-substituted 1,3-thiazoles formed by proton transfer to positions 3 and 5 of the hetero-ring.

  DOI：

  10.1023/a:1023380927159

文献信息

• US9757375B2
  申请人：——

  公开号：US9757375B2

  公开（公告）日：2017-09-12