3-(5-Amino-6-morpholin-4-ylpyrazin-2-yl)phenol | 1252598-09-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(5-Amino-6-morpholin-4-ylpyrazin-2-yl)phenol
• 英文别名: 3-(5-amino-6-morpholin-4-ylpyrazin-2-yl)phenol
• CAS: 1252598-09-6
• 化学式: C₁₄H₁₆N₄O₂
• 分子量: 272.307
• InChiKey: TTYSKNDNWWTSOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  84.5
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-(5-Amino-6-morpholin-4-ylpyrazin-2-yl)phenol 、 在 potassium hydroxide 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 0.33h， 以15%的产率得到3-[3-(4-Methylsulfonylpiperazin-1-yl)-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]phenol
  参考文献：
  名称：

  New use of bis(benzotriazolyl)-1,2-(dialkylamino)ethanes for the synthesis of 2-H-3-dialkylamino imidazo[1,2-a]pyrazine derivatives

  摘要：

  First direct synthesis of 2-H-3-N-dialkyl-imidazo[1,2-a]pyrazines is described. This approach makes use of accessible substituted pyrazines and the assistance of benzotriazole. In such a manner we accomplished the introduction of cyclic amines at C-3 of the scaffold in a convenient formal cyclisation procedure. Detailed examples and utility of this approach are presented herein. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.077
• 作为产物：
  描述：

  2-氨基-5-溴-3-吗啉-4-基吡嗪 、 3-羟基苯硼酸 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium carbonate 作用下， 以 乙二醇二甲醚 为溶剂， 反应 0.17h， 以49%的产率得到3-(5-Amino-6-morpholin-4-ylpyrazin-2-yl)phenol
  参考文献：
  名称：

  New use of bis(benzotriazolyl)-1,2-(dialkylamino)ethanes for the synthesis of 2-H-3-dialkylamino imidazo[1,2-a]pyrazine derivatives

  摘要：

  First direct synthesis of 2-H-3-N-dialkyl-imidazo[1,2-a]pyrazines is described. This approach makes use of accessible substituted pyrazines and the assistance of benzotriazole. In such a manner we accomplished the introduction of cyclic amines at C-3 of the scaffold in a convenient formal cyclisation procedure. Detailed examples and utility of this approach are presented herein. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.077

文献信息

• New use of bis(benzotriazolyl)-1,2-(dialkylamino)ethanes for the synthesis of 2-H-3-dialkylamino imidazo[1,2-a]pyrazine derivatives
  作者：Joaquín Pastor、Sonsoles Rodríguez-Arístegui、Ana Isabel Hernández、Carmen Varela、Antonio Salgado、Sonia Martínez

  DOI：10.1016/j.tetlet.2011.12.077

  日期：2012.2

  First direct synthesis of 2-H-3-N-dialkyl-imidazo[1,2-a]pyrazines is described. This approach makes use of accessible substituted pyrazines and the assistance of benzotriazole. In such a manner we accomplished the introduction of cyclic amines at C-3 of the scaffold in a convenient formal cyclisation procedure. Detailed examples and utility of this approach are presented herein. (C) 2011 Elsevier Ltd. All rights reserved.