4-amino-2-ethoxy-6-(phenethylamino)nicotinonitrile | 1381886-15-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-amino-2-ethoxy-6-(phenethylamino)nicotinonitrile
• 英文别名: 4-Amino-2-ethoxy-6-(2-phenylethylamino)pyridine-3-carbonitrile
• CAS: 1381886-15-2
• 化学式: C₁₆H₁₈N₄O
• 分子量: 282.345
• InChiKey: ZCRBGKLRDJDKNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  84
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  trifluoromethanesulfonic acid 4-amino-5-cyano-6-ethoxypyridin-2-yl ester 、 2-苯乙胺 以 二甲基亚砜 为溶剂， 反应 0.5h， 以72%的产率得到4-amino-2-ethoxy-6-(phenethylamino)nicotinonitrile
  参考文献：
  名称：

  Diaminopyridine-Based Potent and Selective Mps1 Kinase Inhibitors Binding to an Unusual Flipped-Peptide Conformation

  摘要：

  Monopolar spindle 1 (Mps1) is an attractive cancer drug target due to the important role that it plays in centrosome duplication, the spindle assembly checkpoint, and the maintenance of chromosomal stability. A design based on JNK inhibitors with an aminopyridine scaffold and subsequent modifications identified diaminopyridine 9 with an IC50 of 37 nM. The X-ray structure of 9 revealed that the Cys604 carbonyl group of the hinge region flips to form a hydrogen bond with the aniline NH group in 9. Further optimization of 9 led to 12 with improved cellular activity, suitable pharmacokinetic profiles, and good in vivo efficacy in the mouse A549 xenograft model. Moreover, 12 displayed excellent selectivity over 95 kinases, indicating the contribution of its unusual flipped-peptide conformation to its selectivity.

  DOI：

  10.1021/ml3000879

文献信息

• Diaminopyridine-Based Potent and Selective Mps1 Kinase Inhibitors Binding to an Unusual Flipped-Peptide Conformation
  作者：Ken-ichi Kusakabe、Nobuyuki Ide、Yataro Daigo、Takeshi Itoh、Kenichi Higashino、Yousuke Okano、Genta Tadano、Yuki Tachibana、Yuji Sato、Makiko Inoue、Tooru Wada、Motofumi Iguchi、Takayuki Kanazawa、Yukichi Ishioka、Keiji Dohi、Sachie Tagashira、Yasuto Kido、Shingo Sakamoto、Kazuya Yasuo、Masahiro Maeda、Takahiko Yamamoto、Masayo Higaki、Takeshi Endoh、Kazuo Ueda、Takeshi Shiota、Hitoshi Murai、Yusuke Nakamura

  DOI：10.1021/ml3000879

  日期：2012.7.12

  Monopolar spindle 1 (Mps1) is an attractive cancer drug target due to the important role that it plays in centrosome duplication, the spindle assembly checkpoint, and the maintenance of chromosomal stability. A design based on JNK inhibitors with an aminopyridine scaffold and subsequent modifications identified diaminopyridine 9 with an IC50 of 37 nM. The X-ray structure of 9 revealed that the Cys604 carbonyl group of the hinge region flips to form a hydrogen bond with the aniline NH group in 9. Further optimization of 9 led to 12 with improved cellular activity, suitable pharmacokinetic profiles, and good in vivo efficacy in the mouse A549 xenograft model. Moreover, 12 displayed excellent selectivity over 95 kinases, indicating the contribution of its unusual flipped-peptide conformation to its selectivity.