6a-Methyl-4,6-dioxo-5-p-tolyl-1,3a,4,5,6,6a-hexahydro-pyrrolo[3,4-c]pyrazole-3-carboxylic acid methyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 6a-Methyl-4,6-dioxo-5-p-tolyl-1,3a,4,5,6,6a-hexahydro-pyrrolo[3,4-c]pyrazole-3-carboxylic acid methyl ester
• 英文别名: Methyl 6a-methyl-5-(4-methylphenyl)-4,6-dioxo-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrazole-3-carboxylate；methyl 6a-methyl-5-(4-methylphenyl)-4,6-dioxo-1,3a-dihydropyrrolo[3,4-c]pyrazole-3-carboxylate
• 化学式: C₁₅H₁₅N₃O₄
• mdl: MFCD01049396
• 分子量: 301.302
• InChiKey: BRQFQQZGMSCVNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  88.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6a-Methyl-4,6-dioxo-5-p-tolyl-1,3a,4,5,6,6a-hexahydro-pyrrolo[3,4-c]pyrazole-3-carboxylic acid methyl ester 在 氯 作用下， 以 氯仿 为溶剂， 120.0 ℃ 、2.67 kPa 条件下， 生成 (1S,5R,6S)-6-Chloro-1-methyl-2,4-dioxo-3-p-tolyl-3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid methyl ester
  参考文献：
  名称：

  摘要：

  Substituted 2,3,7-triazabicyclo[3.3.0]oct-3-ene-4-carboxylic acid esters react with chlorine and bromine to give the corresponding 4-halo-2,3,7-triazabicyclo[3.3.0]oct-2-ene-4-carboxylates. Heating of the latter to 120 degreesC under reduced pressure leads to elimination of nitrogen molecule and formation of 6-halo-3-azabicyclo[3.1.0]hexane-5-carboxylates.

  DOI：

  10.1023/a:1012354223760

文献信息

• Methods of treating muscular dystrophy
  申请人：Burkin Dean

  公开号：US10028992B2

  公开（公告）日：2018-07-24

  Disclosed herein are α7β1 integrin modulatory agents and methods of using such to treat conditions associated with decreased α7β1 integrin expression or activity, including muscular dystrophy. In one example, methods for treating a subject with muscular dystrophy are disclosed. The methods include administering an effective amount of an α7β1 integrin modulatory agent to the subject with muscular dystrophy, wherein the α7β1 integrin modulatory agent increases α7β1 integrin expression or activity as compared to α7β1 integrin expression or activity prior to treatment, thereby treating the subject with muscular dystrophy. Also disclosed are methods of enhancing muscle regeneration, repair, or maintenance in a subject and methods of enhancing α7β1 integrin expression by use of the disclosed α7β1 integrin modulatory agents. Methods of prospectively preventing or reducing muscle injury or damage in a subject are also disclosed.

  本文公开了α7β1整合素调节剂以及用其治疗与α7β1整合素表达或活性降低有关的疾病（包括肌肉萎缩症）的方法。在一个例子中，公开了治疗肌肉萎缩症患者的方法。该方法包括向肌肉萎缩症患者施用有效量的α7β1整合素调节剂，其中与治疗前的α7β1整合素表达或活性相比，α7β1整合素调节剂可增加α7β1整合素表达或活性，从而治疗肌肉萎缩症患者。还公开了增强受试者肌肉再生、修复或维持的方法，以及通过使用公开的α7β1整合素调节剂增强α7β1整合素表达的方法。还公开了预防或减少受试者肌肉损伤或损害的方法。
• ——
  作者：A. P. Molchanov

  DOI：10.1023/a:1023407032225

  日期：——

  Substituted methyl 2,3,7-triazabicyclo[3.3.0]oct-3-ene-4-carboxylates and 1,2,7-triazaspiro[4.4]-non-2-ene-3-carboxylates react with N-iodosuccinimide (or the system iodine-silver trifluoroacetate) to give, respectively, methyl 6-iodo-3-azabicyclo[3.1.0]hexane-6-carboxylates or methyl 1-iodo-4,6-dioxo-5-azaspiro-[2.4]heptane-1-carboxylates as mixtures of exo and endo isomers.
• METHODS OF TREATING MUSCULAR DYSTROPHY
  申请人：Board of Regents of the Nevada System of Higher Education, on Behalf of the University of Nevada, Reno

  公开号：EP2892525B1

  公开（公告）日：2018-06-13
• US9566310B2
  申请人：——

  公开号：US9566310B2

  公开（公告）日：2017-02-14
• US9707210B2
  申请人：——

  公开号：US9707210B2

  公开（公告）日：2017-07-18