2-methoxy-4-methyl-N-methylbenzamide | 36695-94-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methoxy-4-methyl-N-methylbenzamide
• 英文别名: 2-methoxy-N,4-dimethylbenzamide
• CAS: 36695-94-0
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: BYDRTPRWAHNWFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methoxy-4-methyl-N-methylbenzamide 、 methyloxirane 在 正丁基锂 作用下， 生成 8-Methoxy-3,6-dimethyl-isochroman-1-one
  参考文献：
  名称：

  Bhide, B H; Akolkar, V D; Brahmbhatt, D I, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1992, vol. 31, # 2, p. 116 - 117

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲氧基-4-甲基苯甲酸 、 甲胺 在 氯化亚砜 作用下， 生成 2-methoxy-4-methyl-N-methylbenzamide
  参考文献：
  名称：

  Bhide, B H; Akolkar, V D; Brahmbhatt, D I, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1992, vol. 31, # 2, p. 116 - 117

  摘要：

  DOI：

文献信息

• Ionic Liquids for Separation of Olefin-Paraffin Mixtures
  申请人：Dai Sheng

  公开号：US20110015461A1

  公开（公告）日：2011-01-20

  The invention is directed to an ionic liquid comprising (i) a cationic portion containing a complex of a silver (I) ion and one or more neutral ligands selected from organoamides, organoamines, olefins, and organonitriles, and (ii) an anionic portion having the chemical formula wherein m and n are independently 0 or an integer of 1 or above, and p is 0 or 1, provided that when p is 0, the group —N—SO 2 —(CF 2 ) n CF 3 subtended by p is replaced with an oxide atom connected to the shown sulfur atom. The invention is also directed to a method for separating an olefin from an olefin-paraffin mixture by passing the mixture through a layer of the ionic liquid described above.

  该发明涉及一种离子液体，包括（i）含有银（I）离子的阳离子部分，该离子与来自有机酰胺、有机胺、烯烃和有机腈中选择的一个或多个中性配体形成的络合物，以及（ii）具有化学式的阴离子部分，其中m和n独立地为0或大于1的整数，p为0或1，但当p为0时，由p支撑的基团—N—SO2—(CF2)nCF3将被连接到所示硫原子的氧原子替代。该发明还涉及一种从烯烃烷烃混合物中分离烯烃的方法，通过将混合物经过上述离子液体的一层来实现。
• [EN] NEW IKACH BLOCKERS<br/>[FR] NOUVEAUX BLOQUANTS DE L'IKACH
  申请人：ASTRAZENECA AB

  公开号：WO2012074469A1

  公开（公告）日：2012-06-07

  The invention relates to compounds according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein m, n, R1, R2, R3, R4, R5, x and y are as defined herein. Compounds according to Formula (I) are pharmacologically effective as potassium channel inhibitors, in particular inhibitors of the acetylcholine operated inward rectifying potassium channel current (i.e. IKACh blockers), and are believed to be useful in the treatment of cardiac arrhythmias, in particular supraventricular tacharrhythmias, such as atrial fibrillation and atrial flutter.

  该发明涉及按照公式(I)的化合物或其药用可接受的盐，其中m、n、R1、R2、R3、R4、R5、x和y如本文所定义。公式(I)的化合物在药理学上作为钾通道抑制剂具有药效，特别是乙酰胆碱激活的向内整流钾通道电流的抑制剂（即IKACh阻滞剂），并被认为在治疗心律失常方面有用，特别是在尤为心室上速心律失常，如心房颤动和心房扑动的治疗中。
• COMPOUNDS AND THEIR USE AS IKACH BLOCKERS
  申请人：AstraZeneca AB

  公开号：US20130143858A1

  公开（公告）日：2013-06-06

  The invention relates to compounds according to Formula I: or a pharmaceutically acceptable salt thereof, wherein m, n, R 1 , R 2 , R 3 , R 4 , R 5 , x and y are as defined herein. Compounds according to Formula I are pharmacologically effective as potassium channel inhibitors, in particular inhibitors of the acetylcholine operated inward rectifying potassium channel current (i.e. IKACh blockers), and are believed to be useful in the treatment of cardiac arrhythmias, in particular supraventricular tacharrhythmias, such as atrial fibrillation and atrial flutter.

  本发明涉及以下式I的化合物或其药学上可接受的盐，其中m、n、R1、R2、R3、R4、R5、x和y的定义如本文所述。式I的化合物作为钾通道抑制剂具有药理学作用，特别是乙酰胆碱操作的内向整流钾通道电流（即IKACh阻滞剂），并被认为在治疗心律失常方面有用，特别是上室性心动过速，如心房颤动和心房扑动。
• METHOD FOR PREPARING AROMATIC AMINO ACID DERIVATIVE
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US20220144762A1

  公开（公告）日：2022-05-12

  The present invention provides methods of efficiently producing various optically active aromatic amino acid derivatives by reacting, using an additive, a specific ester compound with an aromatic halide and zinc in the presence of a catalyst. The present invention also provides amino acid derivatives that can be produced by the methods.

  本发明提供了一种通过在催化剂存在下，使用添加剂，将特定酯化合物与芳香卤化物和锌反应的方法，有效地生产各种光学活性芳香族氨基酸衍生物。本发明还提供了可以通过这些方法生产的氨基酸衍生物。
• AMINO ACID HAVING FUNCTIONAL GROUP CAPABLE OF INTERMOLECULAR HYDROGEN BONDING, PEPTIDE COMPOUND CONTAINING SAME AND METHOD FOR PRODUCTION THEREOF
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP3896056A1

  公开（公告）日：2021-10-20

  It has been found that the membrane permeability of peptide compounds can be improved by making at least one of amino acids constituting the peptide compound be an amino acid having a side chain capable of forming an intramolecular hydrogen bond.

  研究发现，通过使构成多肽化合物的氨基酸中至少有一个氨基酸具有能够形成分子内氢键的侧链，可以改善多肽化合物的膜渗透性。