(8-Methoxy-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-methanol | 281658-35-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: (8-Methoxy-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-methanol
• 英文别名: (8-Methoxy-4-propyl-2,3-dihydro-1,4-benzoxazin-2-yl)methanol
• CAS: 281658-35-3
• 化学式: C₁₃H₁₉NO₃
• 分子量: 237.299
• InChiKey: WYYGSHQHNTZYHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (8-Methoxy-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-methanol 在 吡啶 、 三乙胺 作用下， 以 二甲基亚砜 为溶剂， 生成 2-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-ylmethyl]-8-methoxy-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazine
  参考文献：
  名称：

  Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity

  摘要：

  The design, synthesis, and structure-activity relationship of two novel classes of benzoxazine derivatives with dual selective serotonin reuptake inhibitors and 5-HT1A receptor activities are described. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.11.054
• 作为产物：
  描述：

  8-Methoxy-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid ethyl ester 在 锂硼氢 、 三乙胺 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 生成 (8-Methoxy-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-methanol
  参考文献：
  名称：

  Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity

  摘要：

  The design, synthesis, and structure-activity relationship of two novel classes of benzoxazine derivatives with dual selective serotonin reuptake inhibitors and 5-HT1A receptor activities are described. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.11.054

文献信息

• US6221863B1
  申请人：——

  公开号：US6221863B1

  公开（公告）日：2001-04-24
• [EN] 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE DERIVATIVES<br/>[FR] DERIVES DE LA 3,4-DIHYDRO-2H BENZO[1,4]OXAZINE
  申请人：AMERICAN HOME PROD

  公开号：WO2000040581A1

  公开（公告）日：2000-07-13

  Compounds are provided having formula (I) wherein: R1 is hydrogen or halogen; R2 is hydrogen, alkoxy or carboximide; R3 is hydrogen, alkyl, alkylaryl, aryl or substituted aryl; R4 is hydrogen, CN, halogen, or carboximide; and X is CH or N; or a pharmaceutically acceptable salt thereof which are useful as anxiolytic and/or antidepressant agents.
• Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity
  作者：Dahui Zhou、Boyd L. Harrison、Uresh Shah、Terrance H. Andree、Geoffrey A. Hornby、Rosemary Scerni、Lee E. Schechter、Deborah L. Smith、Kelly M. Sullivan、Richard E. Mewshaw

  DOI：10.1016/j.bmcl.2005.11.054

  日期：2006.3

  The design, synthesis, and structure-activity relationship of two novel classes of benzoxazine derivatives with dual selective serotonin reuptake inhibitors and 5-HT1A receptor activities are described. (C) 2005 Elsevier Ltd. All rights reserved.