2-(5-{4-[Amino(imino)methyl]phenyl}-2-thienyl)-1H-benzimidazole-6-carboximidamide dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(5-{4-[Amino(imino)methyl]phenyl}-2-thienyl)-1H-benzimidazole-6-carboximidamide dihydrochloride
• 英文别名: 2-[5-(4-carbamimidoylphenyl)thiophen-2-yl]-3H-benzimidazole-5-carboximidamide
• 化学式: C₁₉H₁₆N₆S
• 分子量: 360.4
• InChiKey: MSQVFIHMHRAMOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  157
• 氢给体数：
  5
• 氢受体数：
  4

文献信息

• Dicationic Compounds For Activity Against Trichomonas Vaginalis
  申请人：Boykin W. David

  公开号：US20070276020A1

  公开（公告）日：2007-11-29

  Dicationic compounds for the treatment of T. vaginalis infections are described. The presently described compounds exhibit in vitro activity against metronidazole-sensitive and -resistant T. vaginalis isolates. Furthermore, the presently described compounds demonstrate IC 50 concentrations that were not elevated in the metronidazole resistant isolate, suggesting that their activity is not affected by parasite mechanisms that confer resistance to 5-nitroimidizoles.

  本文描述了用于治疗T. vaginalis感染的二价化合物。目前描述的化合物在体外对甲硝唑敏感和耐药的T. vaginalis分离株具有活性。此外，目前描述的化合物表现出的IC50浓度在甲硝唑耐药分离株中没有升高，表明它们的活性不受寄生虫机制的影响，这些机制使其对5-硝基咪唑类药物产生耐药性。