[5-Methoxy-2-[2,3,4-trimethoxy-6-(triethylsilyloxymethyl)phenyl]phenyl]methanol | 1233122-69-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [5-Methoxy-2-[2,3,4-trimethoxy-6-(triethylsilyloxymethyl)phenyl]phenyl]methanol
• 英文别名: [5-methoxy-2-[2,3,4-trimethoxy-6-(triethylsilyloxymethyl)phenyl]phenyl]methanol
• CAS: 1233122-69-4
• 化学式: C₂₄H₃₆O₆Si
• 分子量: 448.632
• InChiKey: FUBBDSRGIWWHEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  [5-Methoxy-2-[2,3,4-trimethoxy-6-(triethylsilyloxymethyl)phenyl]phenyl]methanol 在 manganese(IV) oxide 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以91%的产率得到
  参考文献：
  名称：

  Synthesis of antimicrotubule dibenzoxepines

  摘要：

  New dibenzoxepines 5a-i bearing various substituents on B- and C-rings were synthesized in a straightforward manner using a Suzuki-Miyaura coupling, a Grignard addition, and a cyclodehydration as key steps. The antimicrotubule activity of all analogues was evaluated and compared to reference compounds. Compounds 5d-f displayed the highest activity for this type of allocolchicinoids to date. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.039
• 作为产物：
  描述：

  2-溴-5-甲氧基苄醇 、 Triethyl-[[3,4,5-trimethoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methoxy]silane 在 2-双环己基膦-2',6'-二甲氧基联苯 、 Ba(OH)2*8H₂O 、 palladium diacetate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 5.0h， 以81%的产率得到[5-Methoxy-2-[2,3,4-trimethoxy-6-(triethylsilyloxymethyl)phenyl]phenyl]methanol
  参考文献：
  名称：

  Synthesis of antimicrotubule dibenzoxepines

  摘要：

  New dibenzoxepines 5a-i bearing various substituents on B- and C-rings were synthesized in a straightforward manner using a Suzuki-Miyaura coupling, a Grignard addition, and a cyclodehydration as key steps. The antimicrotubule activity of all analogues was evaluated and compared to reference compounds. Compounds 5d-f displayed the highest activity for this type of allocolchicinoids to date. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.039

文献信息

• Synthesis of antimicrotubule dibenzoxepines
  作者：Virginie Colombel、Agnès Joncour、Sylviane Thoret、Joëlle Dubois、Jérôme Bignon、Joanna Wdzieczak-Bakala、Olivier Baudoin

  DOI：10.1016/j.tetlet.2010.04.039

  日期：2010.6

  New dibenzoxepines 5a-i bearing various substituents on B- and C-rings were synthesized in a straightforward manner using a Suzuki-Miyaura coupling, a Grignard addition, and a cyclodehydration as key steps. The antimicrotubule activity of all analogues was evaluated and compared to reference compounds. Compounds 5d-f displayed the highest activity for this type of allocolchicinoids to date. (C) 2010 Elsevier Ltd. All rights reserved.