苯基-2-氨基乙基硒醚 | 81418-58-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯基-2-氨基乙基硒醚
• 中文别名: 2-(苯基硒烷基)乙胺
• 英文名称: 2-aminoethyl-phenyl selenide
• 英文别名: 2-(phenylseleno)ethylamine；phenyl 2-aminoethyl selenide；2-(phenylselanyl)ethanamine；2-(phenylselenyl)ethylamine；(phenylseleno)ethylamine；PAESe；2-phenylselanylethanamine
• CAS: 81418-58-8
• 化学式: C₈H₁₁NSe
• 分子量: 200.142
• InChiKey: ZVWHXJQEPOSKDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.39
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  苯基-2-氨基乙基硒醚 以 二氯甲烷 、 氯苯 为溶剂， 反应 18.5h， 生成
  参考文献：
  名称：

  Indole-2,3-quinodimethanes: a new strategy for the synthesis of tetracyclic systems of indole alkaloids

  摘要：

  DOI：

  10.1021/ja00352a037
• 作为产物：
  描述：

  2-(phenylselanyl)ethanamine hydrochloride 在 potassium hydroxide 作用下， 以 乙醇 为溶剂， 生成 苯基-2-氨基乙基硒醚
  参考文献：
  名称：

  Novel copper(II) and cobalt(II) complexes with selenium substituted imidazolyl imines. The molecular and crystal structure of [N-(2-(phenylseleno)ethyl)-N-(imidazol-2-ylmethylene)amine]copper(II) dichloride

  摘要：

  A series of copper(II) and cobalt(II) complexes with novel selenium containing Schiff base ligands obtained from 2- or 3-aminoalkyl phenyl selenides and imidazole carbaldehydes have been synthesized by the interaction of corresponding organic ligands with MCl2 center dot 6H(2)O (M = Cu, Co). The crystal structure of a copper(II) complex with N-(2-(phenylseleno)ethyl)-N-(imidazolyl-2-ylmethylene)amine has been solved by a single-crystal X-ray diffraction method. The copper(II) ions are coordinated by the imine and imidazole nitrogen atoms of organic ligands and two chloride anions in a distorted square planar geometry. The electrochemical investigations of the synthesized ligands and complexes have been made by cyclic voltammetry method. It is established that the first stage of complexes reduction takes place to metal and the reduced forms of complexes are stable in the solution. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.11.039

文献信息

• Complexes of Pd(II), η⁶-C₆H₆Ru(II), and η⁵-Cp*Rh(III) with Chalcogenated Schiff Bases of Anthracene-9-carbaldehyde and Base-Free Catalytic Transfer Hydrogenation of Aldehydes/Ketones and <i>N</i>-Alkylation of Amines
  作者：Pooja Dubey、Sonu Gupta、Ajai K. Singh

  DOI：10.1021/acs.organomet.8b00908

  日期：2019.2.25

  [(η5-Cp*)Rh(L)Cl][PF6], 7/8 (L = L1/L2 ≡ (N, E) ligand), was formed. Complexes 1–8 were authenticated with 1H, 13C1H}, and 77Se1H} NMR spectroscopy, high-resolution mass spectrometry, elemental analyses, and single-crystal X-ray diffraction. The moisture- and air-insensitive complexes of Pd(II) (1, 2), Ru(II) (3, 4) and Rh(III) (5–8) were thermally stable. Palladium and rhodium (under base-free condition) species

  2-（苯基硫基）乙胺，并用蒽-9-甲醛2-（苯硒基）乙胺的缩合导致Schiff碱[PHS（CH 2）2 C = N-9-C 14 H ^ 9 ]（L1）和[PHSE （CH 2）2 C ＝ N-9-C 14 H 9 ]（L2）。Na 2 [PdCl 4 ]在室温下在丙酮-水混合物中处理L1 / L2 3小时，得到palladacycle [PdCl（C –，N，S / SE）]（1/2 ; L1 / L2 –H =（C –，N，S）/（C –，N，SE））。的反应[（η 6 -C 6 H ^ 6）的RuCl（μ-Cl）的] 2与L1 / L2在甲醇中在室温下（随后加入NH的8小时4 PF 6），得到半夹心络合物[（ η 6 -C 6 H ^ 6）的Ru（大号）CL] [PF 6 ]，3/4：（大号= L1 / L2 ≡（N，E）配体）。的反应[（η 5 -Cp *）的RhCl（μ-Cl）的]
• [EN] CYCLIN-DEPENDENT KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASES CYCLINE-DÉPENDANTES
  申请人：SPV THERAPEUTICS INC

  公开号：WO2020140055A1

  公开（公告）日：2020-07-02

  Described herein are compounds and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, methods of treatment, and medical uses. The compounds described herein are modulators of cyclin-dependent kinases, and are useful in the treatment or alleviation of protein kinase associated disorders, including cancer, infectious diseases, autoimmune diseases, or cardiovascular diseases.

  本文描述了化合物及其药用盐，以及它们的药物组合物，治疗方法和医疗用途。本文描述的化合物是细胞周期依赖性激酶的调节剂，并且在治疗或缓解蛋白激酶相关疾病方面具有用途，包括癌症，传染病，自身免疫疾病或心血管疾病。
• Base free <i>N</i>-alkylation of anilines with ArCH₂OH and transfer hydrogenation of aldehydes/ketones catalyzed by the complexes of η⁵-Cp*Ir(<scp>iii</scp>) with chalcogenated Schiff bases of anthracene-9-carbaldehyde
  作者：Pooja Dubey、Sonu Gupta、Ajai K. Singh

  DOI：10.1039/c7dt04326k

  日期：——

  complexes [(η5-Cp*)Ir(L)Cl][PF6] (3–4) in which L = L1(3)/L2(4) ligates in a bidentate mode. The ligands and complexes were authenticated with HR-MS and NMR spectra [1H, 13C1H} and 77Se1H} (in the case of L2 and its complexes only)]. Single crystal structures of L2 and half sandwich complexes 1–4 were established with X-ray crystallography. Three coordination sites of Ir in each complex are covered

  蒽-9-甲醛与2-（苯硫基/硒代）乙胺的缩合反应生成席夫碱[PhS（CH 2）2 C N-9-C 14 H 9 ]（L1）和[PhSe（CH 2）2 C N-9-C 14 H 9 ]（L2）。它们与[（η反应5 -Cp *）的IrCl（μ-Cl）的] 2和CH 3 COONa，在50℃，接着用NH 4 PF 6，iridacycles，[（η 5 -Cp *）IR（LH ]] [PF 6 ]（1：L= L1 ; 2：L＝L2），结果。在不存在CH的相同的反应3 COONa给出配合物[（η 5 -Cp *）IR（大号）CL] [PF 6 ]（3-4），其中大号= L1（3）/ L2（4）在连接产物双齿模式。配体和配合物已通过HR-MS和NMR光谱[ 1 H，13 C 1 H}和77 Se 1 H}（在L2的情况下）进行了身份验证。及其复合体）]。X射线晶体学确定了L2和半夹心复合物1
• Ultra-small palladium nano-particles synthesized using bulky S/Se and N donor ligands as a stabilizer: application as catalysts for Suzuki–Miyaura coupling
  作者：Preeti Oswal、Aayushi Arora、Jolly Kaushal、Gyandshwar Kumar Rao、Sushil Kumar、Ajai K. Singh、Arun Kumar

  DOI：10.1039/c9ra03498f

  日期：——

  Two chalcogenated ligands L1 and L2 containing anthracene core and amine functionality have been synthesized. Both the ligands have been characterized using 1H and 13C1H} NMR techniques. The structure of L1 has also been corroborated by single crystal X-ray diffraction. Application of L1 and L2 as stabilizers for palladium nano-particles (NPs) has been explored and six different types of NPs 1–6 have

  已经合成了两个含有蒽核心和胺官能团的硫属配体L1和L2 。两种配体均已使用1 H 和13 C 1 H} NMR 技术进行了表征。L1的结构也得到了单晶X射线衍射的证实。已经探索了L1和L2作为钯纳米粒子 (NPs) 稳定剂的应用，并发现了六种不同类型的 NPs 1-6已通过改变稳定剂的量来制备。纳米颗粒已通过 PXRD、EDX 和 HRTEM 技术进行了表征。已发现 1-6 纳米颗粒的尺寸分别在 ~1-2 nm、2-3 nm、4-6 nm、1-2 nm、1-2 nm 和 3-5 nm 范围内。对于苯基硼酸与各种芳基卤化物的 Suzuki-Miyaura 偶联，已经探索了1-6的催化活性。这些纳米颗粒在低催化剂负载量（5 mg）下对各种芳基氯化物/溴化物显示出良好的催化活性。在1-6中，观察到 NPs 1的活性最高，这可能是由于它们的尺寸相对较小且分散的均匀性较高。NPs 最多可循环 5 次催化循环是一个明显的优势。
• Sonogashira (Cu and amine free) and Suzuki coupling in air catalyzed <i>via</i> nanoparticles formed <i>in situ</i> from Pd(<scp>ii</scp>) complexes of chalcogenated Schiff bases of 1-naphthaldehyde and their reduced forms
  作者：Renu Bhaskar、Alpesh K. Sharma、Manoj K. Yadav、Ajai K. Singh

  DOI：10.1039/c7dt02701j

  日期：——

  Suzuki-Miyaura coupling (SMC) of aryl halides in aerobic conditions. The amount of catalyst required for achieving good conversion is 0.01 and 0.05 mol% for SMC and Sonogashira coupling respectively. The conversion of some substrates reached to maximum in 1 and 2 h, respectively for Sonogashira coupling and SMC. Palladacycles resulted in good conversion efficiently. The generation of palladium containing nanoparticles

  1-萘醛与2-（苯硫基/硒基）乙胺的反应产生了不敏感空气和水分的席夫碱，C10H7-1-CH = N-CH2CH2EPh（L1：E = S; L2：E = Se）他们在用NaOAc和Li2PdCl4处理后在室温下得到palladacycles，[Pd（L1-H / L2-H）Cl]（1/2），其中L1 / L2连接为不对称的（C‾，N，E）钳。用硼氢化钠还原L1和L2的> C = N键，得到 -1-CH2NH-CH2CH2EPh（L3：E = S; L4：E = Se）。L3 / L4在室温下的反应类似于L1 / L2的反应，生成复杂的[Pd（L3 / L4）CL2]（3/4），其中配体以双齿（N，E）模式配位。所有复合物的产率均大于85％。发现L1-L4及其配合物1-4的HR-MS，1H，13C 1H}和77Se 1H} NMR谱是特征性的。L1和1-4的结构通过单晶X射线衍