Pyrimidine, 4-methoxy-6-(2-hydroxyphenyl)-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Pyrimidine, 4-methoxy-6-(2-hydroxyphenyl)-
• 英文别名: 2-(6-methoxypyrimidin-4-yl)phenol
• 化学式: C₁₁H₁₀N₂O₂
• 分子量: 202.21
• InChiKey: PSYHDLXCTLOFBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  55.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] METHODS AND COMPOSITIONS FOR MODULATING SPLICING<br/>[FR] MÉTHODES ET COMPOSITIONS PERMETTANT DE MODULER L'ÉPISSAGEÉ
  申请人：SKYHAWK THERAPEUTICS INC

  公开号：WO2019028440A1

  公开（公告）日：2019-02-07

  Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

  本文描述了一种小分子剪接调节剂化合物，可调节由基因编码的mRNA（如pre-mRNA）的剪接，以及利用这些小分子剪接调节剂化合物调节剪接和治疗疾病和病况的方法。
• METHODS AND COMPOSITIONS FOR MODULATING SPLICING
  申请人：Skyhawk Therapeutics, Inc.

  公开号：EP3661509A1

  公开（公告）日：2020-06-10
• COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE
  申请人：PTC Therapeutics, Inc.

  公开号：EP3773552A1

  公开（公告）日：2021-02-17
• [EN] COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE<br/>[FR] COMPOSÉS PERMETTANT DE TRAITER LA MALADIE DE HUNTINGTON
  申请人：PTC THERAPEUTICS INC

  公开号：WO2019191229A1

  公开（公告）日：2019-10-03

  The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.