[2,4-Dioxo-3-(2-trimethylsilanyl-ethyl)-thiazolidin-5-yl]-acetic acid | 313271-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: [2,4-Dioxo-3-(2-trimethylsilanyl-ethyl)-thiazolidin-5-yl]-acetic acid
• 英文别名: 2-[2,4-Dioxo-3-(2-trimethylsilylethyl)-1,3-thiazolidin-5-yl]acetic acid；2-[2,4-dioxo-3-(2-trimethylsilylethyl)-1,3-thiazolidin-5-yl]acetic acid
• CAS: 313271-28-2
• 化学式: C₁₀H₁₇NO₄SSi
• 分子量: 275.401
• InChiKey: PUBFNGGHTOGBJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.86
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  H-Phe-Gly-OMe*HCl 、 [2,4-Dioxo-3-(2-trimethylsilanyl-ethyl)-thiazolidin-5-yl]-acetic acid 在 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以54%的产率得到((S)-2-{2-[2,4-Dioxo-3-(2-trimethylsilanyl-ethyl)-thiazolidin-5-yl]-acetylamino}-3-phenyl-propionylamino)-acetic acid methyl ester
  参考文献：
  名称：

  Solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential PPAR ligands

  摘要：

  Solution- and solid-phase methods for the preparation of peptide-substituted thiazolidinediones have been developed as an approach towards the preparation of a library of these compounds as potential ligands for the peroxisome proliferator-activated receptors (PPARs). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00440-6
• 作为产物：
  描述：

  5-Allyl-3-(2-trimethylsilanyl-ethyl)-thiazolidine-2,4-dione 在 potassium permanganate 、 臭氧 作用下， 生成 [2,4-Dioxo-3-(2-trimethylsilanyl-ethyl)-thiazolidin-5-yl]-acetic acid
  参考文献：
  名称：

  Solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential PPAR ligands

  摘要：

  Solution- and solid-phase methods for the preparation of peptide-substituted thiazolidinediones have been developed as an approach towards the preparation of a library of these compounds as potential ligands for the peroxisome proliferator-activated receptors (PPARs). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00440-6

文献信息

• Solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential PPAR ligands
  作者：Debra L Mohler、Gang Shen、Anthony K Dotse

  DOI：10.1016/s0960-894x(00)00440-6

  日期：2000.10

  Solution- and solid-phase methods for the preparation of peptide-substituted thiazolidinediones have been developed as an approach towards the preparation of a library of these compounds as potential ligands for the peroxisome proliferator-activated receptors (PPARs). (C) 2000 Elsevier Science Ltd. All rights reserved.