Azoture de l'acide 2-diethylphosphonophenylethanoique | 75226-79-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Azoture de l'acide 2-diethylphosphonophenylethanoique
• 英文别名: 2-Diethoxyphosphoryl-2-phenylacetyl azide
• CAS: 75226-79-8
• 化学式: C₁₂H₁₆N₃O₄P
• 分子量: 297.25
• InChiKey: BTFXZWQWEAMPRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  67
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Azoture de l'acide 2-diethylphosphonophenylethanoique 以 苯 为溶剂， 反应 2.0h， 以92%的产率得到(+/-)-α-(diethoxyphosphonyl)benzyl isocyanate
  参考文献：
  名称：

  Synthese de peptides modifies incorporant un motif phosphore n ou c terminal

  摘要：

  A general route to phosphopeptids with a 2-oxoalkylphosphonate moiety at the terminal N-aminogroup or with a 1-aminoalkylphosphonate moiety at the terminal C-carboxyl group is described. The method allows the preparation of various phosphopeptids with an alpha-alkylated carbon atom on the P-C bond from the very available dialkylphosphonoalcanoic acids as starting products.

  DOI：

  10.1016/s0040-4020(01)92278-1
• 作为产物：
  描述：

  (Chlorocarbonyl-phenyl-methyl)-phosphonic acid diethyl ester 在 sodium azide 作用下， 以 乙醚 、 水 为溶剂， 反应 2.0h， 以78.5%的产率得到Azoture de l'acide 2-diethylphosphonophenylethanoique
  参考文献：
  名称：

  Synthese de peptides modifies incorporant un motif phosphore n ou c terminal

  摘要：

  A general route to phosphopeptids with a 2-oxoalkylphosphonate moiety at the terminal N-aminogroup or with a 1-aminoalkylphosphonate moiety at the terminal C-carboxyl group is described. The method allows the preparation of various phosphopeptids with an alpha-alkylated carbon atom on the P-C bond from the very available dialkylphosphonoalcanoic acids as starting products.

  DOI：

  10.1016/s0040-4020(01)92278-1

文献信息

• KOLODYAZHNYJ O. I.; YAKOVLEV V. N.; KUXAR V. P., ZH. OBSHCH. XIMII, 1980, 50, HO 6, 1418-1419
  作者：KOLODYAZHNYJ O. I.、 YAKOVLEV V. N.、 KUXAR V. P.

  DOI：——

  日期：——
• Synthese de peptides modifies incorporant un motif phosphore n ou c terminal
  作者：Ph. Coutrot、C. Grison、C. Charbonnier-Gérardin

  DOI：10.1016/s0040-4020(01)92278-1

  日期：1992.11

  A general route to phosphopeptids with a 2-oxoalkylphosphonate moiety at the terminal N-aminogroup or with a 1-aminoalkylphosphonate moiety at the terminal C-carboxyl group is described. The method allows the preparation of various phosphopeptids with an alpha-alkylated carbon atom on the P-C bond from the very available dialkylphosphonoalcanoic acids as starting products.