1-Methyl-2-thio-thymin | 54563-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-Methyl-2-thio-thymin
• 英文别名: 1-Methyl-2-thiothymin；1,5-dimethyl-2-sulfanylidenepyrimidin-4-one
• CAS: 54563-80-3
• 化学式: C₆H₈N₂OS
• 分子量: 156.208
• InChiKey: QAMXFYYZTPYIKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-Methyl-N'-(3-methoxy-2-methyl-acryloyl)-thioharnstoff 在 sodium hydroxide 作用下， 生成 1-Methyl-2-thio-thymin
  参考文献：
  名称：

  32.嘌呤，嘧啶和乙二醛。第七部分 2-硫尿嘧啶和2-硫胸腺嘧啶的新合成

  摘要：

  DOI：

  10.1039/jr9580000153

文献信息

• Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation
  申请人：Coull James M.

  公开号：US20080085837A1

  公开（公告）日：2008-04-10

  This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.
• 4'-ALLENE-SUBSTITUTED NUCLEOSIDE DERIVATIVES
  申请人：Qiu Yao-Ling

  公开号：US20100074889A1

  公开（公告）日：2010-03-25

  The present invention discloses compounds of formula (I), or its β-L enantiomer, or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, solvate, prodrug, or combination thereof: which inhibit, preventing or treating abnormal cellular proliferation and/or a viral infection, particularly by HIV, HCV or HBV. Consequently, the compounds of the present invention interfere with the replication cycle of a virus and are also useful as antiviral agents, or interfere with host cellular biochemical process and are also useful as antiproliferative agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from viral infection and/or cell proliferation. The invention also relates to methods of treating a viral infection and/or cell proliferation in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral/anti-proliferative compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral infection in a subject in need of such therapy with said compounds.
• CHEMICALLY MODIFIED OLIGONUCLEOTIDES AND USES THEREOF
  申请人：Manoharan Muthiah

  公开号：US20110065774A1

  公开（公告）日：2011-03-17

  This invention relates generally to chemically oligonucleotides (e.g., modified oligonucleotides) useful for augmenting activity of a target gene.
• RNA COMPOSITIONS FOR MODULATING IMMUNE RESPONSE
  申请人：Manoharan Muthiah

  公开号：US20110166198A1

  公开（公告）日：2011-07-07

  This invention features modified iRNA agents that modulate an immune response, methods of making and identifying iRNA agents that modulate an immune response, and methods of using the iRNA agents to modulate an immune response.
• CHEMICALLY MODIFIED OLIGONUCLEOTIDES AND SMALL MOLECULES FOR USE IN REDUCING MICRO RNA ACTIVITY LEVELS AND USES THEREOF
  申请人：Manoharan Muthiah

  公开号：US20110257244A1

  公开（公告）日：2011-10-20

  This invention relates generally to chemically modified oligonucleotides useful for modulating activity of microRNAs and pre-microRNAs. More particularly, the invention relates to single stranded chemically modified oligonucleotides for inhibiting microRNA and pre-microRNA activity and to methods of making and using the modified oligonucleotides.