4-tridecylbenzoic acid | 62443-07-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-tridecylbenzoic acid
• CAS: 62443-07-6
• 化学式: C₂₀H₃₂O₂
• 分子量: 304.473
• InChiKey: JKPOJUJMUNDYMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-tridecylbenzoic acid 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 生成 4-chloro-1,3-phenylene bis(4-((4-dodecylbenzoyl)oxy)benzoate)
  参考文献：
  名称：

  Nematic phases of bent-core mesogens

  摘要：

  源自4-氰基水杨酚的弯曲核介质与末端烷基链的合成及其通过偏振显微镜、XRD和电光方法进行研究。短链化合物仅具有能冷却到室温的向列相。这些向列相与普通的向列相相似，仅具有最近邻的相关性（N），而长链化合物形成SmC型的赛博聚集体，这些赛博向列相（NcybC）可以被视为强烈分碎的SmC相。链长依赖性以及温度依赖性的从N相到NcybC相的结构转变是连续的，并且与XRD图案中小角散射的位置和强度的变化相关。此外，从赛博向列相到不同类型的非极性和倾斜的层状相（SmC(I)和SmC(II)）的温度依赖性逐步转变被观察到，中间状态为由拉伸但尚未融合的赛博聚集体（CybC）组成的介相。这增进了对由弯曲核分子形成的向列相的性质和特殊性能的理解，以及它们向层状相转变的过程，并为在室温下形成自发或电场诱导的双轴向列相的新材料铺平了道路。

  DOI：

  10.1039/b923262a
• 作为产物：
  描述：

  溴代十二烷 在 盐酸 、 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 、 水 为溶剂， 反应 2.5h， 生成 4-tridecylbenzoic acid
  参考文献：
  名称：

  苯乙烯取代的1,3,4-恶二唑固定在热可逆发光有机胶中及其意外的光催化重排

  摘要：

  已经设计并研究了一系列苯乙烯取代的1,3,4-恶二唑作为新型低分子量有机胶凝剂。通过UV / Vis吸收和发光光谱学表征了所得热可逆有机凝胶的光物理性质。出人意料的是，恶二唑的胶凝能力取决于苯乙烯部分的存在，因为所研究的恶二唑的胶凝在不存在的情况下不会发生。凝胶形成伴随着超分子状态下有机胶凝剂荧光的改变。凝胶的紫外线照射通过串联[4 + 2]和[3 + 2]级联反应引起固定的带有苯乙烯部分的1,3,4-恶二唑的重排。辐射后凝胶的结构改变和颜色变化也很明显。

  DOI：

  10.1002/chem.201202246

文献信息

• Treatment of viral infections by modulation of host cell metabolic pathways
  申请人：THE TRUSTEES OF PRINCETON UNIVERSITY

  公开号：EP2581081A2

  公开（公告）日：2013-04-17

  Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in "suicide" of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models.; Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.

  描述了病毒感染时某些代谢物浓度和通量的变化。所涉及的代谢途径中的宿主细胞酶被选为干预目标；即恢复代谢通量以不利于病毒复制，或进一步改变代谢通量导致病毒感染细胞（而非未感染细胞）"自杀 "以限制病毒传播。虽然可以选择相关代谢途径中的任何一种酶，但这些代谢途径关键控制点上的关键酶更适合作为候选的抗病毒药物靶点。这些酶的抑制剂可用于逆转或重定向病毒感染的影响。候选药物通过体外和宿主细胞以及动物模型中的筛选试验进行抗病毒活性测试；然后用动物模型测试候选化合物在预防和治疗病毒感染方面的疗效。展示酶抑制剂的抗病毒活性。
• BENZOBIS(THIADIAZOLE) DERIVATIVE, INK CONTAINING SAME, AND ORGANIC ELECTRONIC DEVICE USING SAME
  申请人：UBE Industries, Ltd.

  公开号：EP3181569A1

  公开（公告）日：2017-06-21

  An object of the present invention is to provide a benzobis(thiadiazole) derivative, which has an excellent mobility of electron (field-effect mobility) and also has an excellent stability in the atmosphere. The present invention relates to a benzobis(thiadiazole) derivative or the like, which has cyclic imide structures annelated to an aromatic ring in the molecule, represented by the following general formula (1) or (2) wherein R, A and Z represent predetermined groups.

  本发明的目的是提供一种苯并双(噻二唑)衍生物，它具有优异的电子迁移率(场效应迁移率)，在大气中也具有优异的稳定性。本发明涉及一种苯并双(噻二唑)衍生物或类似物，其分子中的环状亚胺结构与芳香环环化，由下式通式(1)或(2)表示，其中 R、A 和 Z 代表预定基团。
• Liquid crystalline optical film, compensating film for liquid crystal display and liquid crystal display
  申请人：NIPPON OIL COMPANY, LIMITED

  公开号：EP0758013B1

  公开（公告）日：2000-10-11
• TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS
  申请人：The Trustees of Princeton University

  公开号：US20160346309A1

  公开（公告）日：2016-12-01

  Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.
• BENZOBIS(THIADIAZOLE) DERIVATIVE, INK COMPRISING THE SAME, AND ORGANIC ELECTRONIC DEVICE USING THE SAME
  申请人：UBE INDUSTRIES, LTD.

  公开号：US20180219160A1

  公开（公告）日：2018-08-02

  An object of the present invention is to provide a benzobis(thiadiazole) derivative, which has an excellent mobility of electron (field-effect mobility) and also has an excellent stability in the atmosphere. The present invention relates to a benzobis(thiadiazole) derivative or the like, which has cyclic imide structures annelated to an aromatic ring in the molecule, represented by the following general formula (1) or (2) wherein R, A and Z represent predetermined groups.