n-Propyl 2-phenylaethyl methylamin | 73676-27-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: n-Propyl 2-phenylaethyl methylamin
• 英文别名: N-methyl-N-(2-phenylethyl)propan-1-amine
• CAS: 73676-27-4
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: CNOBAJSQVAPYLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  n-苯乙基氨基甲酸乙酯 、 丙酸乙酯 生成 n-Propyl 2-phenylaethyl methylamin
  参考文献：
  名称：

  由胺，内酰胺和氨基甲酸酯一锅合成叔胺

  摘要：

  已经开发了由酰胺，内酰胺和氨基甲酸酯一锅法合成不对称叔胺的方法。对于所检查的所有情况，该反应都是通用的，但含N-芳基的实例除外，该实例无法通过该方法进行操作。

  DOI：

  10.1016/s0040-4039(01)95418-8

文献信息

• Aminopyridine Derivatives
  申请人：Evans David Michael

  公开号：US20100076015A1

  公开（公告）日：2010-03-25

  The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (such as asthma or COPD); and methods of treating patients with such compounds; wherein R 1 -R 11 are as defined herein.

  本发明提供了式(I)的化合物：包括这些化合物的组合物；在治疗（如哮喘或COPD）中使用这些化合物；以及使用这些化合物治疗患者的方法；其中R1-R11如本文所定义。
• NOVEL TETRAHYDROPYRAZOLO [3,4-b] AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
  申请人：Bolea Christelle

  公开号：US20130267499A1

  公开（公告）日：2013-10-10

  The present invention relates to novel compounds of Formula (I), wherein M, A and Y are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR 4 ”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR 4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR 4 is involved.

  本发明涉及公式（I）的新化合物，其中M，A和Y如公式（I）中所定义；发明化合物是代谢型谷氨酸受体-亚型4（“mGluR4”）的调节剂，可用于治疗或预防中枢神经系统疾病以及其他受mGluR4受体调节的疾病。本发明还涉及制药组合物以及使用这些化合物制造药物的用途，以及使用这些化合物预防和治疗涉及mGluR4的疾病的用途。
• Benzimidazole derivatives and their use as a medicament
  申请人：Poitout Lydie

  公开号：US20090170922A1

  公开（公告）日：2009-07-02

  A subject of the present application is new benzimidazole derivatives of formula in which A, Y, R 1 , R 2 , R 3 and R 4 represent different variable groups. These products have an antagonist activity of GnRH (Gonadotropin-Releasing Hormone). The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament.

  本申请的主题是公式中A、Y、R1、R2、R3和R4代表不同变量基团的新苯并咪唑衍生物。这些产物具有GnRH（促性腺激素释放激素）的拮抗活性。本发明还涉及含有所述产物的制药组合物及其用于制备药物的用途。
• PEG oligomer-fentanyl conjugates
  申请人：Nektar Therapeutics

  公开号：EP2628489A1

  公开（公告）日：2013-08-21

  This invention provides conjugates wherein the opioid agonist fentanyl is covalently attached to poly(ethylene glycol) oligomers. A conjugate of the invention when administered by any of a number of administration routes, exhibits characteristics that are different from those of the opioid agonist not attached to the PEG oligomers.

  本发明提供了阿片类激动剂芬太尼与聚乙二醇低聚物共价连接的共轭物。本发明的共轭物在通过多种给药途径中的任何一种给药时，都会表现出与未附着在聚乙二醇低聚物上的阿片类激动剂不同的特性。
• HOLLAND H. L.; JOHNSON G. B., TETRAHEDRON LETT., 1979, NO 36, 3395-3396
  作者：HOLLAND H. L.、 JOHNSON G. B.

  DOI：——

  日期：——