N-[3-(1H-benzimidazol-2-yl)phenyl]-4-methoxybenzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-[3-(1H-benzimidazol-2-yl)phenyl]-4-methoxybenzenesulfonamide
• 化学式: C₂₀H₁₇N₃O₃S
• 分子量: 379.4
• InChiKey: MLFHFOMXDLPJJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  92.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• STEROIDAL COMPOUNDS WITH POTENT ANDROGEN RECEPTOR DOWN-REGULATION AND ANTI PROSTATE CANCER ACTIVITY
  申请人：University of Maryland, Baltimore

  公开号：EP3514147A1

  公开（公告）日：2019-07-24

  Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant, induce apoptosis and inhibit proliferation of inhibiting proliferation and migration of androgen sensitive cancer cells. The steroid compounds and nonsteroid compounds may be agents for the prevention and/or treatment of cancer, including prostate cancer, castration resistant prostate cancer, bladder cancer, pancreatic cancer, hepatocellular carcinoma, benign prostatic hyperplasia (BPH), Kennedy's disease, androgenetic alopecia, breast cancer, androgen-insensitive syndrome, and spinal and bulbar muscular atrophy.

  非类固醇和类固醇化合物可导致雄激素受体（AR）（包括全长和剪接变体）的下调，诱导凋亡并抑制对雄激素敏感的癌细胞的增殖和迁移。类固醇化合物和非类固醇化合物可作为预防和/或治疗癌症的药物，包括前列腺癌、阉割抗性前列腺癌、膀胱癌、胰腺癌、肝细胞癌、良性前列腺增生症（BPH）、肯尼迪病、雄激素性脱发、乳腺癌、雄激素不敏感综合征以及脊柱和球部肌肉萎缩症。
• Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity
  申请人：UNIVERSITY OF MARYLAND, BALTIMORE

  公开号：US10617685B2

  公开（公告）日：2020-04-14

  Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant, induce apoptosis and inhibit proliferation of inhibiting proliferation and migration of androgen sensitive cancer cells. The steroid compounds and nonsteroid compounds may be agents for the prevention and/or treatment of cancer, including prostate cancer, castration resistant prostate cancer, bladder cancer, pancreatic cancer, hepatocellular carcinoma, benign prostatic hyperplasia (BPH), Kennedy's disease, androgenetic alopecia, breast cancer, androgen-insensitive syndrome, and spinal and bulbar muscular atrophy.

  非类固醇和类固醇化合物可导致雄激素受体（AR）（包括全长和剪接变体）的下调，诱导凋亡并抑制对雄激素敏感的癌细胞的增殖和迁移。类固醇化合物和非类固醇化合物可作为预防和/或治疗癌症的药物，包括前列腺癌、阉割抗性前列腺癌、膀胱癌、胰腺癌、肝细胞癌、良性前列腺增生症（BPH）、肯尼迪病、雄激素性脱发、乳腺癌、雄激素不敏感综合征以及脊柱和球部肌肉萎缩症。
• NONSTEROIDAL AND STEROIDAL COMPOUNDS WITH POTENT ANDROGEN RECEPTOR DOWN-REGULATION AND ANTI PROSTATE CANCER ACTIVITY
  申请人：University of Maryland, Baltimore

  公开号：EP2991644A2

  公开（公告）日：2016-03-09
• US9694005B2
  申请人：——

  公开号：US9694005B2

  公开（公告）日：2017-07-04
• [EN] NONSTEROIDAL AND STEROIDAL COMPOUNDS WITH POTENT ANDROGEN RECEPTOR DOWN-REGULATION AND ANTI PROSTATE CANCER ACTIVITY<br/>[FR] COMPOSÉS NON-STÉROÏDIENS ET STÉROÏDIENS PUISSANTS EN TERMES DE RÉGULATION À LA BAISSE DU RÉCEPTEUR DES ANDROGÈNES ET D'ACTIVITÉ CONTRE LE CANCER DE LA PROSTATE
  申请人：UNIV MARYLAND

  公开号：WO2014165815A2

  公开（公告）日：2014-10-09

  Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant, induce apoptosis and inhibit proliferation of inhibiting proliferation and migration of androgen sensitive cancer cells. The steroid compounds and nonsteroid compounds may be agents for the prevention and/or treatment of cancer, including prostate cancer, castration resistant prostate cancer, bladder cancer, pancreatic cancer, hepatocellular carcinoma, benign prostatic hyperplasia (BPH), Kennedy's disease, androgenetic alopecia, breast cancer, androgen-insensitive syndrome, and spinal and bulbar muscular atrophy.