3-Phenyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-ylmethyl)-4,5-dihydro-isoxazole | 145732-24-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Phenyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-ylmethyl)-4,5-dihydro-isoxazole
• 英文别名: 3-Phenyl-5-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-4,5-dihydro-1,2-oxazole
• CAS: 145732-24-7
• 化学式: C₁₆H₂₂BNO₃
• 分子量: 287.167
• InChiKey: CEXLRRMSTUYHNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.27
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  40
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Phenyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-ylmethyl)-4,5-dihydro-isoxazole 在 sodium hydroxide 、 双氧水 作用下， 以 四氢呋喃 为溶剂， 以75%的产率得到(3-phenyl-4,5-dihydro-isoxazol-5-yl)-methanol
  参考文献：
  名称：

  Preparation and 1-carbon homologation of boronic ester substituted Δ2-isoxazolines: The 1,3 dipolar cycloaddition of nitrile oxides to vinyl boronic esters

  摘要：

  The dipolar cycloaddition of a variety of nitrile oxides to pinacol vinylboronate (2) is described. In addition, the 1-carbon homologation of the boronic ester substituted DELTA2-isoxazolines obtained from the cycloadditions has been carried out employing iodomethyllithium.

  DOI：

  10.1016/s0040-4039(00)60901-2
• 作为产物：
  描述：

  3-phenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-isoxazoline 以69%的产率得到
  参考文献：
  名称：

  Wallace Richard H., Battle William, Synth. Commun, 25 (1995) N 1, S 127-133

  摘要：

  DOI：

文献信息

• Wallace Richard H., Battle William, Synth. Commun, 25 (1995) N 1, S 127-133
  作者：Wallace Richard H., Battle William

  DOI：——

  日期：——
• Preparation and 1-carbon homologation of boronic ester substituted Δ2-isoxazolines: The 1,3 dipolar cycloaddition of nitrile oxides to vinyl boronic esters
  作者：Richard H. Wallace、K.K. Zong

  DOI：10.1016/s0040-4039(00)60901-2

  日期：1992.11

  The dipolar cycloaddition of a variety of nitrile oxides to pinacol vinylboronate (2) is described. In addition, the 1-carbon homologation of the boronic ester substituted DELTA2-isoxazolines obtained from the cycloadditions has been carried out employing iodomethyllithium.