2-(1-hydroxy-3H-2,1-benzoxaborol-3-yl)prop-2-enal | 1246404-49-8

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 2-(1-hydroxy-3H-2,1-benzoxaborol-3-yl)prop-2-enal
• CAS: 1246404-49-8
• 化学式: C₁₀H₉BO₃
• 分子量: 187.991
• InChiKey: VYDQBCPPEGWSHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲酰基苯硼酸 、 丙烯醛 在 三乙烯二胺 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以20%的产率得到2-(1-hydroxy-3H-2,1-benzoxaborol-3-yl)prop-2-enal
  参考文献：
  名称：

  Development of practical methodologies for the synthesis of functionalized benzoboroxoles

  摘要：

  2-Formylphenylboronic acids upon reaction with activated olefins such as acrylates, methyl vinyl ketone, and acrylonitrile provide functionalized benzoboroxoles. The corresponding homologated benzoboroxoles were synthesized via the reaction of 2-formylphenylboronic acids with alpha-bromomethylacrylates. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.06.077

文献信息

• Development of practical methodologies for the synthesis of functionalized benzoboroxoles
  作者：J. Sravan Kumar、Christopher M. Bashian、Michael A. Corsello、Subash C. Jonnalagadda、Venkatram R. Mereddy

  DOI：10.1016/j.tetlet.2010.06.077

  日期：2010.8

  2-Formylphenylboronic acids upon reaction with activated olefins such as acrylates, methyl vinyl ketone, and acrylonitrile provide functionalized benzoboroxoles. The corresponding homologated benzoboroxoles were synthesized via the reaction of 2-formylphenylboronic acids with alpha-bromomethylacrylates. (C) 2010 Elsevier Ltd. All rights reserved.