N-(3-Methoxy-phenyl)-benzimidoyl chloride | 80819-63-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-Methoxy-phenyl)-benzimidoyl chloride
• 英文别名: N-(3-methoxyphenyl)-benzimidoyl chloride；N-(3-methoxyphenyl)benzenecarboximidoyl chloride
• CAS: 80819-63-2
• 化学式: C₁₄H₁₂ClNO
• 分子量: 245.708
• InChiKey: XTGDDAVAEUDABG-UHFFFAOYSA-N

物化性质

• 沸点：
  376.8±44.0 °C(Predicted)
• 密度：
  1.11±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(3-Methoxy-phenyl)-benzimidoyl chloride 在 四氯化钛 作用下， 以 乙醚 、 苯 为溶剂， 反应 3.0h， 生成 7-methoxy-4-amino-2-phenylquinazoline
  参考文献：
  名称：

  Synthesis and Basicity of 4-Amino-2-phenylquinazolines

  摘要：

  A new group of 6- and 7-substituted compounds of 4-amino-2-phenylquinazoline were synthesized by reaction of N-arylbenzimidoyl chlorides with cyanamide in the presence of TiCl4. The products were identified by spectroscopic methods, their dissociation constants were determined and are discussed.

  DOI：

  10.1007/s007060070067
• 作为产物：
  描述：

  N-(3-甲氧基苯基)苯甲酰胺 在 五氯化磷 作用下， 以 苯 为溶剂， 生成 N-(3-Methoxy-phenyl)-benzimidoyl chloride
  参考文献：
  名称：

  Synthesis and Basicity of 4-Amino-2-phenylquinazolines

  摘要：

  A new group of 6- and 7-substituted compounds of 4-amino-2-phenylquinazoline were synthesized by reaction of N-arylbenzimidoyl chlorides with cyanamide in the presence of TiCl4. The products were identified by spectroscopic methods, their dissociation constants were determined and are discussed.

  DOI：

  10.1007/s007060070067

文献信息

• Naphthyridone derivatives
  申请人：USV Pharmaceutical Corporation

  公开号：US04304914A1

  公开（公告）日：1981-12-08

  Compounds of the formula ##STR1## wherein each of R, R.sub.1 and R.sub.2 is independently H, alkyl, alkenyl, alkoxy, halo, hydroxy, trifluoromethyl, amino, alkylamino, cyano and nitro; R.sub.3 is carbalkoxy, carboxamide alkanoyl, trifluoromethyl and cyano; and Ar is heteroaryl or ##STR2## wherein R.sub.4 and R.sub.5 have the same meaning as each of R, R.sub.1 and R.sub.2 ; and acid addition salts thereof have cardiotonic and hypertensive activity.

  式（I）的化合物，其中R、R.sub.1和R.sub.2各自独立地为H、烷基、烯基、烷氧基、卤素、羟基、三氟甲基、氨基、烷基氨基、氰基和硝基；R.sub.3为羧酰烷氧基、酰胺基烷酰基、三氟甲基和氰基；Ar为杂芳基或式（II）其中R.sub.4和R.sub.5与R、R.sub.1和R.sub.2的含义相同；以及它们的酸盐具有心脏强心和高血压活性。
• Synthesis and Basicity of 4-Amino-2-phenylquinazolines
  作者：Wojciech Zieliński、Agnieszka Kudelko

  DOI：10.1007/s007060070067

  日期：2000.8.22

  A new group of 6- and 7-substituted compounds of 4-amino-2-phenylquinazoline were synthesized by reaction of N-arylbenzimidoyl chlorides with cyanamide in the presence of TiCl4. The products were identified by spectroscopic methods, their dissociation constants were determined and are discussed.