Diisobutyl-phenyl-phosphin | 7650-78-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Diisobutyl-phenyl-phosphin
• 英文别名: (di-isobutyl)(phenyl)phosphine；Phosphine, bis(2-methylpropyl)phenyl-；bis(2-methylpropyl)-phenylphosphane
• CAS: 7650-78-4
• 化学式: C₁₄H₂₃P
• 分子量: 222.31
• InChiKey: IRDQEMSRVZZPED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  Diisobutyl-phenyl-phosphin 在 F₆Mo 作用下， 以 二氯甲烷 为溶剂， 生成 difluorodiisobutyl(phenyl)-l5-phosphane
  参考文献：
  名称：

  Mathey,F.; Bensoam,J., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1972, vol. 274, p. 1095 - 1098

  摘要：

  DOI：
• 作为产物：
  描述：

  ISOBUTYLMAGNESIUM BROMIDE 、 苯基二氯化磷 生成 Diisobutyl-phenyl-phosphin
  参考文献：
  名称：

  Schindlbauer,H.; Hajek,G., Chemische Berichte, 1963, vol. 96, p. 2601 - 2606

  摘要：

  DOI：
• 作为试剂：
  描述：

  4-氯苯甲醚 、 potassium isopropyltrifluoroborate 在 palladium diacetate 、 caesium carbonate 、 Diisobutyl-phenyl-phosphin 作用下， 以 水 、 甲苯 为溶剂， 反应 72.0h， 生成 对丙基苯甲醚 、 4-异丙基苯甲醚
  参考文献：
  名称：

  Efficient Cross-Coupling of Secondary Alkyltrifluoroborates with Aryl Chlorides—Reaction Discovery Using Parallel Microscale Experimentation

  摘要：

  Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in particular, using secondary alkylboron partners. A ligand-dependent beta-hydride elimination/reinsertion mechanism was implicated in the cross-coupling of more hindered substrates, leading to isomeric mixtures of coupled products in some cases.

  DOI：

  10.1021/ja8031423

文献信息

• Steric and Electronic Effects of Unidentate Tertiary Phosphine Ligands on Chemical and Absorption Spectral Properties of Their Mixed Cobalt(III) Complexes with Acetylacetonate Ions
  作者：Katsuaki Katoh、Hirofumi Sugiura、Kazuo Kashiwabara、Junnosuke Fujita

  DOI：10.1246/bcsj.57.3580

  日期：1984.12

  phosphine–cobalt(III) complexes containing acetylacetonate ions were prepared. The complexes are grouped into four types; (A) cis- and trans-([Co(acac)2(PRnPh3−n)2]+, (B) trans-[Co(acac)2(H2O)(PRnPh3−n)]+, (C) trans-[Co(acac)2(L)(PMe2Ph)n+, and (D) trans-(P,P)-[Co(acac)(CN)2(PRnPh3−n)2] (acac: acetylacetonate ion, R: CH3(Me), C2H5(Et), n-C3H7(Pr), i-C3H7(Pri), n-C4H9(Bu), i-C4H9(Bui), c-C6H11 (Cy), Ph: C6H5, L: NH3

  制备了大量含有乙酰丙酮离子的新型单齿叔膦-钴（III）配合物。这些复合体分为四种类型；(A) 顺式和反式 ([Co(acac)2(PRnPh3−n)2]+, (B) trans-[Co(acac)2(H2O)(PRnPh3−n)]+, (C) trans -[Co(acac)2(L)(PMe2Ph)n+，和 (D) trans-(P,P)-[Co(acac)(CN)2(PRnPh3−n)2]（acac：乙酰丙酮离子，R : CH3(Me), C2H5(Et), n-C3H7(Pr), i- (Pri), n-C4H9(Bu), i- (Bui), c-C6H11 (Cy), Ph: C6H5, L: NH3, NH2, C5H5N(py), NCS−). A 型配合物形成不同比例的顺式和反式异构体，这取决于膦配体的体积和碱度，以及配合物 R=Me 的比例和 Et 进行了一些详细的检查。A
• PROCESS FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE THROUGH COUPLING USING TRANSITION METAL CATALYST
  申请人：Komiyama Masato

  公开号：US20110313169A1

  公开（公告）日：2011-12-22

  A process for efficiently producing, through few steps either a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or an intermediate therefore. The process is a novel coupling process which comprises subjecting a compound represented by formula (1) to coupling reaction with a compound represented by formula (2) in the presence of a transition metal compound to thereby obtain a compound represented by formula (3).

  一种高效生产黄嘌呤氧化酶抑制剂或其中间体的方法，该抑制剂是治疗高尿酸血症的药物。该方法是一种新型偶联过程，包括将式（1）表示的化合物与式（2）表示的化合物在过渡金属化合物存在下进行偶联反应，从而获得式（3）表示的化合物。
• METHOD FOR PRODUCING CATALYST FOR CYCLIC CARBONATE SYNTHESIS
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US20160108071A1

  公开（公告）日：2016-04-21

  The present invention provides a method for easily and inexpensively producing a heterogeneous catalyst used to synthesize a cyclic carbonate by reacting an epoxide with carbon dioxide and having excellent catalyst activity; a catalyst obtained using said manufacturing method; and a method for synthesizing a cyclic carbonate using said catalyst. A method for producing a catalyst that is used for the purpose of synthesizing a cyclic carbonate by subjecting to a reaction an epoxide with carbon dioxide, said method comprising the following steps (a) and (b): (a) a step of obtaining a catalyst precursor having a haloalkyl group or a haloaryl group by reacting a silane compound with a silica gel in the presence of xylene, the silane compound having a haloalkyl group or a haloaryl group and (b) a step of obtaining a catalyst for synthesizing a cyclic carbonate by reacting the catalyst precursor obtained in step (a) with a tertiary phosphine.

  本发明提供了一种用于通过将环氧化合物与二氧化碳反应来合成环状碳酸酯的异质催化剂的简便且廉价的生产方法；采用所述制备方法获得的催化剂；以及使用该催化剂合成环状碳酸酯的方法。用于生产一种用于合成环状碳酸酯的催化剂的方法，通过将环氧化合物与二氧化碳反应，该方法包括以下步骤(a)和(b)：(a)通过在二甲苯存在下将硅烷化合物与二氧化硅反应以获得具有卤代烷基或卤代芳基的催化剂前驱体的步骤，其中所述硅烷化合物具有卤代烷基或卤代芳基；以及(b)通过将步骤(a)中获得的催化剂前驱体与三膦反应以获得用于合成环状碳酸酯的催化剂的步骤。
• METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING PALLADIUM COMPOUND
  申请人：Komiyama Masato

  公开号：US20130158272A1

  公开（公告）日：2013-06-20

  The present invention provides a method for producing a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or intermediates of the same, said method being efficient and using a short process. The present invention is a novel coupling method for obtaining a compound represented by formula (3) by bringing about a coupling reaction between a compound represented by formula (1) and a compound represented by formula (2), in the presence of a palladium compound, a ligand capable of coordinating to the palladium compound, a base, a C 1 -C 40 carboxylic acid, and at least one kind of additive.

  本发明提供了一种生产黄嘌呤氧化酶抑制剂的方法，该抑制剂是治疗高尿酸血症的药物，或者其中间体，该方法高效且使用流程简短。本发明是一种新型耦合方法，通过在钯化合物、能够配位到钯化合物的配体、碱、C1-C40羧酸和至少一种添加剂的存在下，在式（1）所代表的化合物和式（2）所代表的化合物之间引发耦合反应，从而获得式（3）所代表的化合物。
• Phosphinegold(I)salts, process for their preparation and compositions containing them
  申请人：SMITHKLINE BECKMAN CORPORATION

  公开号：EP0003897A1

  公开（公告）日：1979-09-05

  (Pyridine) (trisubstituted phosphine) gold (I) salts. These compounds have antiarthritic activity. They can be prepared by reacting a halo (trisubstituted phosphine) gold (I) compound with a silver salt and pyridine.

  (吡啶）（三取代膦）金（I）盐。这些化合物具有抗关节炎活性。它们可以通过卤代（三取代膦）金（I）化合物与银盐和吡啶反应制备。