Phenylacetyl-phosphonic acid | 67532-95-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phenylacetyl-phosphonic acid
• 英文别名: Phenacetylphosphonic acid；(2-phenylacetyl)phosphonic acid
• CAS: 67532-95-0
• 化学式: C₈H₉O₄P
• 分子量: 200.131
• InChiKey: HKSPESBFWPBYLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Phenylacetyl-phosphonic acid 、 甲胺 生成 N(α)-Methyl-α-amino-β-phenylethylphosphorsaeure
  参考文献：
  名称：

  Organophosphorus analogs of biologically active compounds

  摘要：

  DOI：

  10.1007/bf00952486
• 作为产物：
  描述：

  在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 Phenylacetyl-phosphonic acid
  参考文献：
  名称：

  Synthesis of ?-ketophosphonic acids

  摘要：

  DOI：

  10.1007/bf00923378

文献信息

• Bis-phosphonate compounds
  申请人：——

  公开号：US20020042539A1

  公开（公告）日：2002-04-11

  The present invention provides a pharmaceutical compound, or pharmaceutically acceptable salt thereof, for use in medicine, wherein said compound is of formula I 1 wherein R is a pharmaceutically active moiety; Ar is an aromatic moiety; X is a linker group; and Y is a moiety comprising two phosphonate groups. Further aspects of the invention relate to a method for palliative and curative treatment of bone disorders and cancer related disorders, such as breast cancer.

  本发明提供了一种药物化合物，或其在医学上可接受的盐，用于药物，其中所述化合物为以下公式I1： 其中R为药用活性基团；Ar为芳香基团；X为连接基团；Y为包含两个膦酸酯基团的基团。该发明的进一步方面涉及一种用于缓解和治疗骨骼疾病和癌症相关疾病的方法，例如乳腺癌。
• O-, N- and carboxyl derivatives of thienamycin sulfoxide and sulfone, their preparation and pharmaceuticals containing said compounds
  申请人：Merck & Co., Inc.

  公开号：EP0001265A1

  公开（公告）日：1979-04-04

  Disclosed are O-, N- and substituted carboxyl derivatives of thienamycin sulfoxide (I, n =1) and thienamycin sulfone (I, n=2): wherein n is 1 or 2; R and R are independently selected from hydrogen and acyl; R is, interalia, hydrogen, acyl or alkyl; X is O or NR; and R is, inter alia, hydrogen or a pharmaceutically acceptable salt or ester moiety. Such derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.

  公开了噻吩霉素亚砜（I，n =1）和噻吩霉素砜（I，n =2）的 O-、N-和取代的羧基衍生物： 其中 n 为 1 或 2；R 和 R 独立选自氢和酰基；R 除其他外为氢、酰基或烷基；X 为 O 或 NR；R 除其他外为氢或药学上可接受的盐或酯分子。此类衍生物可用作抗生素。此外，还公开了制备此类衍生物的工艺、包含此类衍生物的药物组合物以及治疗方法，包括在需要抗生素效果时施用此类衍生物和组合物。
• 6- and 6,6- disubstituted-2-substituted-pen-2-em-3-carboxylic acids; processes for their preparation and pharmaceutical compositions containing such compounds
  申请人：Merck & Co., Inc.

  公开号：EP0002210A1

  公开（公告）日：1979-06-13

  Disclosed are 6- and 6.6-disubstituted-2-substituted-pen-2-em-3-carboxylic acids of the following structure: wherein: R1 and R2 are independently selected from hydrogen, -NHR1' (R1' is H or acyl), alkyl, alkoxyl. aralkyl, aryl. heterocyclyl and heterocycfyl-alkyl: R3 is selected from hydrogen, -R, -OR, -SR. -NR2; R is substituted and unsubstituted alkyl, aryl, aralkyl, hetero-heterocyclyl, or heterocyclylalkyl; n is 0 or 1: when n=1, R3 is not -SR. Such compounds and their pharmaceutically acceptable salt, and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

  本发明公开了具有以下结构的 6-和 6.6-二取代-2-取代-戊-2-烯-3-羧酸： 其中R1和R2独立地选自氢、-NHR1'（R1'为H或酰基）、烷基、烷氧基、芳基、杂环基和杂环烷基：R3 选自氢、-R、-OR、-SR.-NR2；R 是取代和未取代的烷基、芳基、烷基、杂杂环基或杂环烷基；n 是 0 或 1：当 n=1 时，R3 不是 -SR。此类化合物及其药学上可接受的盐和酯衍生物可用作抗生素。此外，还公开了制备此类化合物的工艺、包含此类化合物的药物组合物以及治疗方法，包括在需要抗生素效果时施用此类化合物和组合物。
• 6-(1'-Hydroxyethyl)-3-substituted amino-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid
  申请人：Merck & Co., Inc.

  公开号：EP0134301A1

  公开（公告）日：1985-03-20

  Disclosed are 6-(1'-hydroxyethyl)-3-substituted amino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acids (I) : wherein R' and R" are independently selected from H, substituted and unsubstituted alkyl and aralkyl groups, or together form a substituted or unsubstituted cyclic group. Such compounds and their O- and carboxyl derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds and pharmaceutical compositions comprising such compounds.

  公开了 6-(1'-羟乙基)-3-取代氨基-1-氮杂双环[3.2.0]庚-2-烯-7-酮-2-羧酸 (I) ： 其中，R'和 R "独立地选自 H、取代和未取代的烷基和芳烷基，或共同形成取代或未取代的环状基团。此类化合物及其 O-和羧基衍生物可用作抗生素。还公开了制备此类化合物的工艺和包含此类化合物的药物组合物。
• US3974151A
  申请人：——

  公开号：US3974151A

  公开（公告）日：1976-08-10