2-[[2-[[4,5-Dimethoxy-2-[[2-(oxan-2-yloxymethyl)phenyl]methyl]phenyl]methyl]phenyl]methoxy]oxane | 1027924-92-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[[2-[[4,5-Dimethoxy-2-[[2-(oxan-2-yloxymethyl)phenyl]methyl]phenyl]methyl]phenyl]methoxy]oxane
• CAS: 1027924-92-0
• 化学式: C₃₄H₄₂O₆
• 分子量: 546.704
• InChiKey: KLXBLVYCFUEDII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  40
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[[2-[[4,5-Dimethoxy-2-[[2-(oxan-2-yloxymethyl)phenyl]methyl]phenyl]methyl]phenyl]methoxy]oxane 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 4,5-Dimethoxy-1,2-bis<2-(hydroxymethyl)benzyl>benzene
  参考文献：
  名称：

  Orthocyclophanes. 4. Functionalization of [1n]Orthocyclophanes on the Aromatic Rings

  摘要：

  Functionalization of the [1(n)]orthocyclophanes ([1(n)]OCPs) has been accomplished by introducing groups on the aromatic rings of the cycles. Dilithiation of dibromoaromatic 10 followed by condensation with various aromatic dialdehydes, such as 14, 20, and 30, gave rise to [1(n)]OCP cycles bearing methoxy groups on the aromatic rings. Several polymethoxy[1(n)]OCPs have been prepared that are reasonably soluble inorganic solvents, in contrast to their parent hydrocarbons. Since methoxy functions can be converted to phenolic hydroxy groups and then to other functionalities, the methoxy derivatives may have broad applications to the modification of [1(n)]OCPs for the preparation of a variety of supramolecules.

  DOI：

  10.1021/jo00095a026
• 作为产物：
  描述：

  2-(tetrahydropyranyloxy)methylbromobenzene 、 1,2-二甲氧基-4,5-双(氯甲基)苯 在 copper(l) iodide 、 magnesium 作用下， 生成 2-[[2-[[4,5-Dimethoxy-2-[[2-(oxan-2-yloxymethyl)phenyl]methyl]phenyl]methyl]phenyl]methoxy]oxane
  参考文献：
  名称：

  Orthocyclophanes. 4. Functionalization of [1n]Orthocyclophanes on the Aromatic Rings

  摘要：

  Functionalization of the [1(n)]orthocyclophanes ([1(n)]OCPs) has been accomplished by introducing groups on the aromatic rings of the cycles. Dilithiation of dibromoaromatic 10 followed by condensation with various aromatic dialdehydes, such as 14, 20, and 30, gave rise to [1(n)]OCP cycles bearing methoxy groups on the aromatic rings. Several polymethoxy[1(n)]OCPs have been prepared that are reasonably soluble inorganic solvents, in contrast to their parent hydrocarbons. Since methoxy functions can be converted to phenolic hydroxy groups and then to other functionalities, the methoxy derivatives may have broad applications to the modification of [1(n)]OCPs for the preparation of a variety of supramolecules.

  DOI：

  10.1021/jo00095a026

文献信息

• Orthocyclophanes. 4. Functionalization of [1n]Orthocyclophanes on the Aromatic Rings
  作者：Woo Young Lee、Chang Hee Park、Eun Hee Kim

  DOI：10.1021/jo00095a026

  日期：1994.8

  Functionalization of the [1(n)]orthocyclophanes ([1(n)]OCPs) has been accomplished by introducing groups on the aromatic rings of the cycles. Dilithiation of dibromoaromatic 10 followed by condensation with various aromatic dialdehydes, such as 14, 20, and 30, gave rise to [1(n)]OCP cycles bearing methoxy groups on the aromatic rings. Several polymethoxy[1(n)]OCPs have been prepared that are reasonably soluble inorganic solvents, in contrast to their parent hydrocarbons. Since methoxy functions can be converted to phenolic hydroxy groups and then to other functionalities, the methoxy derivatives may have broad applications to the modification of [1(n)]OCPs for the preparation of a variety of supramolecules.