2-(diethoxyphosphoryl)acetate | 105968-44-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 2-(diethoxyphosphoryl)acetate
• 英文别名: (diethoxyphosphoryl)acetate；diethoxyphosphorylethanoate；diethylphosphonoacetate；2-diethoxyphosphorylacetate
• CAS: 105968-44-3
• 化学式: C₆H₁₂O₅P
• 分子量: 195.132
• InChiKey: DVQMPWOLBFKUMM-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  75.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(diethoxyphosphoryl)acetate 、 sodium;hydride 、 乙基溴苯 在 乙酸乙酯 、 水 、 Brine 、 crude residue 、 hexanes 作用下， 以 四氢呋喃 为溶剂， 反应 25.17h， 生成 2-(diethoxy-phosphoryl)-4-phenyl-butyric acid tert-butyl ester
  参考文献：
  名称：

  Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX

  摘要：

  本发明涉及琥珀酸和戊二酸及其类似物的衍生物，其具有以下一般式：用作PHEX的抑制剂。这些衍生物有助于促进骨量的生成，并用于治疗或预防与磷酸盐代谢缺陷有关的疾病或病况。本发明还公开了制备方法和中间体。

  公开号：

  US20060287280A1
• 作为产物：
  描述：

  O-methyl diethylphosphonoacetohydroxamate 在 碳酸氢钠 作用下， 生成 2-(diethoxyphosphoryl)acetate
  参考文献：
  名称：

  Chen, Ravit; Breuer, Eli, Phosphorus, Sulfur and Silicon and the Related Elements, 1996, vol. 111, p. 165

  摘要：

  DOI：

文献信息

• Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives
  申请人：Schubert Gerrit

  公开号：US20050124681A1

  公开（公告）日：2005-06-09

  A method and apparatus for preventing board warpage during the application and curing or drying of liquid epoxies, or the like, on printed circuit boards using a clamping fixture assembly, which includes at least one clamping fixture support and at least one clamping fixture overlay. If desired, a plurality of printed circuit boards may be processed using an appropriate clamping fixture assembly. Furthermore, the clamping fixture may be constructed so a slight bow or curvature thereof can counter either a convex or concave bow or curvature of the printed circuit board. In the method, at least one printed circuit board is mounted to a clamping fixture support whereby a clamping fixture overlay is placed on top of the first printed circuit board.

  一种防止印刷电路板在液态环氧树脂的施加、固化或干燥过程中变形的方法和装置，使用夹紧夹具组件，其中包括至少一个夹紧夹具支架和至少一个夹紧夹具叠层。如有需要，可以使用适当的夹紧夹具组件处理多个印刷电路板。此外，夹紧夹具可以构造成略微弯曲或弯曲，以对抗印刷电路板的凸或凹弯曲。在该方法中，至少一个印刷电路板被安装到夹紧夹具支架上，夹紧夹具叠层被放置在第一个印刷电路板的顶部。
• Aryl sulfamate derivatives
  申请人：——

  公开号：US20040254241A1

  公开（公告）日：2004-12-16

  The present invention provides an aryl sulfamate derivative represented by Formula (I) 1 (wherein R r and R s , which may be the same or different, each represent a hydrogen atom or lower alkyl R 1 , R 2 , R 3 and R 4 , which may be the same or different, each represent a hydrogen atom, lower alkyl, a halogen atom, nitro, cyano, azido, or the like, R 5 represents a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted lower cycloalkyl, or the like, R 6 represents a hydrogen atom, substituted or unsubstituted alkyl, a halogen atom, or the like, or R 5 and R 6 are joined to form a bond, and R 7 represents X 1 NR 23 R 24 or COR 26 ), or a pharmaceutically acceptable salt thereof.

  本发明提供一种由式（I）1表示的芳基磺酰胺衍生物（其中Rr和Rs，可以相同也可以不同，均表示氢原子或低级烷基，R1、R2、R3和R4，可以相同也可以不同，均表示氢原子、低级烷基、卤素原子、硝基、氰基、叠氮基等，R5表示氢原子、取代或未取代的烷基、取代或未取代的低环烷基等，R6表示氢原子、取代或未取代的烷基、卤素原子等，或R5和R6结合形成键，R7表示X1NR23R24或COR26，或其药学上可接受的盐）。
• Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex
  申请人：Biomep Inc.

  公开号：US20040186301A1

  公开（公告）日：2004-09-23

  The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: 1 useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for preparation and intermediates are also disclosed.

  本发明涉及琥珀酸和戊二酸的衍生物及其类似物，具有以下一般公式：1，用作PHEX的抑制剂。这些衍生物对于促进骨量的生成以及治疗或预防与磷酸盐代谢缺陷有关的疾病或疾病条件是有用的。还公开了制备方法和中间体。
• Chen, Ravit; Breuer, Eli, Phosphorus, Sulfur and Silicon and the Related Elements, 1996, vol. 111, p. 165
  作者：Chen, Ravit、Breuer, Eli

  DOI：——

  日期：——
• Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX
  申请人：Gravel Denis

  公开号：US20060287280A1

  公开（公告）日：2006-12-21

  The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for preparation and intermediates are also disclosed.

  本发明涉及琥珀酸和戊二酸及其类似物的衍生物，其具有以下一般式：用作PHEX的抑制剂。这些衍生物有助于促进骨量的生成，并用于治疗或预防与磷酸盐代谢缺陷有关的疾病或病况。本发明还公开了制备方法和中间体。