ethyl (8-((2-(dimethylamino)ethyl)amino)-2,3-diphenylpyrido[2,3-b]pyrazin-6-yl)carbamate | 1347749-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶吡嗪类
• 英文名称: ethyl (8-((2-(dimethylamino)ethyl)amino)-2,3-diphenylpyrido[2,3-b]pyrazin-6-yl)carbamate
• 英文别名: ethyl N-[8-[2-(dimethylamino)ethylamino]-2,3-diphenylpyrido[2,3-b]pyrazin-6-yl]carbamate
• CAS: 1347749-97-6
• 化学式: C₂₆H₂₈N₆O₂
• 分子量: 456.547
• InChiKey: HHICWLZMNOCMIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  92.3
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate 在 氢气 作用下， 以 乙醇 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 40.0h， 生成 ethyl (8-((2-(dimethylamino)ethyl)amino)-2,3-diphenylpyrido[2,3-b]pyrazin-6-yl)carbamate
  参考文献：
  名称：

  Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors

  摘要：

  A series of pyridopyrazine and pyrimidothiazine derivatives have been synthesized and their activity against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro antibacterial activity against Mtb H37Ra and Mtb H(37)Rv are reported. Certain analogs described herein showed moderate to good inhibitory activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.09.062

文献信息

• BENZIMIDAZOLES THAT ENHANCE THE ACTIVITY OF OLIGONUCLEOTIDES
  申请人：The University of North Carolina at Chapel Hill

  公开号：US20190343868A1

  公开（公告）日：2019-11-14

  This disclosure is directed to methods, compounds and compositions for delivering nucleic acids to a cell of interest. In particular, it provides salts that are particularly effective in delivering nucleic acids to cells in the lung for disorders such as cystic fibrosis (CF).

  本公开涉及将核酸传递到感兴趣的细胞的方法、化合物和组合物。特别地，它提供了对于像囊性纤维化（CF）这样的肺部疾病中将核酸传递到细胞特别有效的盐。
• Small molecules that enhance the activity of oligonucleotides
  申请人：The University of North Carolina at Chapel Hill

  公开号：US10266823B2

  公开（公告）日：2019-04-23

  Methods of administering an oligonucleotide of interest into a cell in vitro or in vivo are described. In the methods, a small organic compound active agent is concurrently administered to the cell in an amount effective to increase the delivery of the oligonucleotide into the cell, and/or increase the activity of said oligonucleotide in the cell. Compositions useful for carrying out the method are also described.

  本文描述了在体外或体内将感兴趣的寡核苷酸注入细胞的方法。在这些方法中，一种小型有机化合物活性剂被同时施用到细胞中，其有效量可增加寡核苷酸向细胞的输送，和/或增加所述寡核苷酸在细胞中的活性。此外，还描述了用于实施该方法的组合物。
• Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
  申请人：Pfizer Inc.

  公开号：US10952972B2

  公开（公告）日：2021-03-23

  The present disclosure generally relates to nanoparticles comprising an endo-lysosomal escape agent, a nucleic acid, and a polymer. Other aspects include methods of making and using such nanoparticles.

  本公开一般涉及由内溶酶体逃逸剂、核酸和聚合物组成的纳米颗粒。其他方面包括制造和使用这种纳米颗粒的方法。
• Benzimidazoles that enhance the activity of oligonucleotides
  申请人：The University of North Carolina at Chapel Hill

  公开号：US11040056B2

  公开（公告）日：2021-06-22

  This disclosure is directed to methods, compounds and compositions for delivering nucleic acids to a cell of interest. In particular, it provides salts that are particularly effective in delivering nucleic acids to cells in the lung for disorders such as cystic fibrosis (CF).

  本公开涉及将核酸递送至相关细胞的方法、化合物和组合物。特别是，它提供了在将核酸递送至肺部细胞以治疗囊性纤维化（CF）等疾病方面特别有效的盐类。
• THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME
  申请人：Pfizer Inc.

  公开号：US20170049709A1

  公开（公告）日：2017-02-23

  The present disclosure generally relates to nanoparticles comprising an endo-lysosomal escape agent, a nucleic acid, and a polymer. Other aspects include methods of making and using such nanoparticles.