1H-Benzimidazole, 1-((2,6-difluorophenyl)methyl)-4-methyl-2-(4-pyridinyl)- | 199594-75-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1H-Benzimidazole, 1-((2,6-difluorophenyl)methyl)-4-methyl-2-(4-pyridinyl)-
• 英文别名: 1-[(2,6-difluorophenyl)methyl]-4-methyl-2-pyridin-4-ylbenzimidazole
• CAS: 199594-75-7
• 化学式: C₂₀H₁₅F₂N₃
• 分子量: 335.3
• InChiKey: KVKNXIWANBJVAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase
  申请人：——

  公开号：US20030191160A1

  公开（公告）日：2003-10-09

  The present invention provides compositions and methods for the treatment of HIV infection. In particular, the present invention provides non-nucleoside inhibitors of reverse transcriptase (RT), as well as methods to treat HIV infection using these non-nucleoside inhibitors of RT. In preferred embodiments, the present invention provides a novel class of substituted benzimidazoles, effective in the inhibition of human immunodeficiency virus (HIV) RT.

  本发明提供了治疗HIV感染的组合物和方法。特别是，本发明提供了反转录酶（RT）非核苷类抑制剂，以及使用这些非核苷类RT抑制剂治疗HIV感染的方法。在优选实施例中，本发明提供了一类新型的取代苯并咪唑，能够有效抑制人类免疫缺陷病毒（HIV）RT。
• SUBSTITUTED BENZIMIDAZOLES AS NON-NUCLEOSIDE INHIBITORS OF REVERSE TRANSCRIPTASE
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP0963371A1

  公开（公告）日：1999-12-15
• US6369235B1
  申请人：——

  公开号：US6369235B1

  公开（公告）日：2002-04-09
• US6894068B2
  申请人：——

  公开号：US6894068B2

  公开（公告）日：2005-05-17
• [EN] SUBSTITUTED BENZIMIDAZOLES AS NON-NUCLEOSIDE INHIBITORS OF REVERSE TRANSCRIPTASE<br/>[FR] BENZIMIDAZOLES SUBSTITUES COMME INHIBITEURS NON NUCLEOSIDIQUES DE TRANSCRIPTASE INVERSE
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：WO1998037072A1

  公开（公告）日：1998-08-27

  (EN) The present invention provides compositions and methods for the treatment of HIV infection. In particular, the present invention provides non-nucleoside inhibitors of reverse transcriptase (RT), as well as methods to treat HIV infection using these non-nucleoside inhibitors of RT. In preferred embodiments, the present invention provides a novel class of substituted benzimidazoles, effective in the inhibition of human immunodeficiency virus (HIV) RT.(FR) La présente invention concerne des compositions et méthodes de traitement de l'infection par VIH. En particulier, la présente invention concerne des inhibiteurs non nucléosidiques de transcriptase inverse (RT), ainsi que des méthodes de traitement d'infection par VIH par utilisation de ces inhibiteurs non nucléosidiques de RT. Dans des modes de réalisation préférés, la présente invention décrit une nouvelle classe de benzimidazoles, efficaces dans l'inhibition de la RT du virus de l'immunodéficience humaine (VIH).