methyl 2-formyl-3,5-dimethoxy-4-methylbenzoate | 79564-26-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-formyl-3,5-dimethoxy-4-methylbenzoate
• CAS: 79564-26-4
• 化学式: C₁₂H₁₄O₅
• 分子量: 238.24
• InChiKey: CCRBZBSWKUGLJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 2-formyl-3,5-dimethoxy-4-methylbenzoate 在 吡啶盐酸盐 作用下， 反应 6.0h， 以50%的产率得到methyl 2-formyl-3,5-dihydroxy-4-methylbenzoate
  参考文献：
  名称：

  Murthy, A. R. K.; Rao, G. S. R. Subba, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 7, p. 569 - 571

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 2-hydroxymethyl-3,5-dimethoxy-4-methylbenzoate 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以80%的产率得到methyl 2-formyl-3,5-dimethoxy-4-methylbenzoate
  参考文献：
  名称：

  Murthy, A. R. K.; Rao, G. S. R. Subba, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 7, p. 569 - 571

  摘要：

  DOI：

文献信息

• MURTHY, A. R. K.;RAO, G. S. R. SUBRA, INDIAN J. CHEM., 1981, 20, N 7, 569-571
  作者：MURTHY, A. R. K.、RAO, G. S. R. SUBRA

  DOI：——

  日期：——
• Chlorins processing fused ring systems useful as photoselective compounds for photodynamic therapy
  申请人：Robinson C. Byron

  公开号：US20050020560A1

  公开（公告）日：2005-01-27

  The present invention provides a process of preparation of naphthochlorins and other chlorins with annelated ring systems useful for photodynamic therapy and the compounds themselves. The method for producing naphthochlorin compounds include contacting compounds such as meso-(2′-hydroxymethyl)phenyl porphyrin or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at least one acid catalyst at sufficient temperature for a sufficient time to yield the desired conversion. In a similar manner chlorins possessing annelated ring systems may be made from compounds such as meso-(2′-hydroxymethyl)aryl porphyrins or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures described herein provide new routes for synthesizing naphthochlorins and chlorins with annelated ring systems.
• CHLORINS POSSESSING FUSED RING SYSTEMS USEFUL AS PHOTOSELECTIVE COMPOUNDS FOR PHOTODYNAMIC THERAPY
  申请人：Robinson Byron C.

  公开号：US20080275232A1

  公开（公告）日：2008-11-06

  The present invention provides a process of preparation of naphthochlorins and other chlorins with annelated ring systems useful for photodynamic therapy and the compounds themselves. The method for producing naphthochlorin compounds include contacting compounds such as meso-(2′-hydroxymethyl)phenyl porphyrin or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at least one acid catalyst at sufficient temperature for a sufficient time to yield the desired conversion. In a similar manner chlorins possessing annelated ring systems may be made from compounds such as meso-(2′-hydroxymethyl)aryl porphyrins or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures described herein provide new routes for synthesizing naphthochlorins and chlorins with annelated ring systems.
• US6794505B1
  申请人：——

  公开号：US6794505B1

  公开（公告）日：2004-09-21
• US7521551B2
  申请人：——

  公开号：US7521551B2

  公开（公告）日：2009-04-21