9-甲基-N-丙烷-2-基嘌呤-6-胺 | 5418-12-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 9-甲基-N-丙烷-2-基嘌呤-6-胺
• 英文名称: isopropyl-(9-methyl-9H-purin-6-yl)-amine
• 英文别名: 9-Methyl-n-(propan-2-yl)-9h-purin-6-amine；9-methyl-N-propan-2-ylpurin-6-amine
• CAS: 5418-12-2
• 化学式: C₉H₁₃N₅
• mdl: MFCD20545824
• 分子量: 191.236
• InChiKey: IDGWDEZZNNDVFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.444
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-氯-4-甲基嘧啶-4,5-二胺,6-氯-4-甲基-4,5-二氨基嘧啶 在 乙酸酐 作用下， 生成 9-甲基-N-丙烷-2-基嘌呤-6-胺
  参考文献：
  名称：

  Potential Purine Antagonists. IV. Synthesis of Some 9-Methyl-6-substituted-purines¹

  摘要：

  DOI：

  10.1021/ja01559a069

文献信息

• HIGH TEMPERATURE SELECTION OF NUCLEOTIDE-SUPPORTED CARBOHYDRATE VACCINES AND RESULTING GLYCOSYLATED OLIGONUCLEOTIDES
  申请人：BRANDEIS UNIVERSITY

  公开号：US20160304874A1

  公开（公告）日：2016-10-20

  The invention relates to an oligonucleotide including one or more modified nucleoside bases having the structure -B-L-A wherein for each of the modified nucleosides A is independently a monosaccharide or oligosaccharide, L is a linker molecule, and B is independently a pyrimidine or pyridine base linked to the sugar-phosphate backbone of the oligonucleotide; and wherein the oligonucleotide binds specifically to a carbohydrate-binding monoclonal antibody with an affinity of less than 100 nM. Immunogenic conjugates that include the oligonucleotide, and pharmaceutical compositions that include the oligonucleotide or the immunogenic conjugate are also disclosed. Various method of using the oligonucleotides, immunogenic conjugates, and pharmaceutical compositions are disclosed, including inducing an immune response, inhibiting viral or bacterial infection, treating a cancerous condition, and detecting a neutralizing antibody. A method is also disclosed for selecting the oligonucleotides using an alternative Selection of Modified Aptamers (SELMA).
• Potential Purine Antagonists. IV. Synthesis of Some 9-Methyl-6-substituted-purines¹
  作者：Roland K. Robins、Hsi Hu Lin

  DOI：10.1021/ja01559a069

  日期：1957.1