Biphenyl-4-ylmethyl-pyridin-2-yl-amine | 164733-65-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Biphenyl-4-ylmethyl-pyridin-2-yl-amine
• 英文别名: 2-Pyridinamine, N-([1,1'-biphenyl]-4-ylmethyl)-；N-[(4-phenylphenyl)methyl]pyridin-2-amine
• CAS: 164733-65-7
• 化学式: C₁₈H₁₆N₂
• 分子量: 260.338
• InChiKey: ZJASERVWIGKVLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  [1-Biphenyl-4-yl-meth-(Z)-ylidene]-pyridin-2-yl-amine 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以59%的产率得到Biphenyl-4-ylmethyl-pyridin-2-yl-amine
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. XI. Synthesis and antimicrobial activity of N-heteroaryl benzylamines and their Schiff bases

  摘要：

  The synthesis and antimicrobial activity of new N-heteroaryl benzylamines and their Schiff bases are reported. Antifungal data were compared with those obtained with miconazole ketoconazole, enilconazole and imazalil sulfate; which showed that some of the tested compounds possessed moderate activity against strains of Candida albicans, Candida sp and good activity against isolates of plant pathogenic fungi, In contrast the synthesized compounds showed poor antibacterial activity, except for 3j which exhibited a better activity than nalidixic acid used as positive control. The results obtained are discussed on the basis of structure-activity relationships.

  DOI：

  10.1016/0223-5234(96)88217-1

文献信息

• High Active Palladium Composite and Catalytic Applications on the Synthesis of Substituted Aminopyridine Derivatives Through Borrowing Hydrogen Strategy
  作者：Jiajia Pan、Jiahao Li、Xiao-Feng Xia、Wei Zeng、Dawei Wang

  DOI：10.1007/s10562-022-04024-0

  日期：——

  An unsymmetrical 2-(diphenylphosphino) aminobenzothiazole (DPA) was used to synthesize a heterogeneous and recyclable palladium composite through co-doping C3N4. The resulting palladium composite (DPA-Pd@g-C3N4) was carefully characterized by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, N2 sorption isotherms, thermogravimetricanalysis

  使用不对称的2-(二苯基膦基)氨基苯并噻唑(DPA)通过共掺杂C 3 N 4合成非均相且可回收的钯复合材料。通过扫描电子显微镜、透射电子显微镜、X 射线光电子能谱、X 射线衍射、N 2吸附等温线、热重分析和能量色散 X 射线光谱对所得钯复合材料 (DPA-Pd@gC 3 N 4 ) 进行了仔细表征. 此外，复合 DPA-Pd@gC 3 N 4通过借氢策略成功应用于2-氨基吡啶与苯甲醇反应合成N-取代氨基吡啶衍生物。 图形概要 通过C 3 N 4掺杂Pd合成了相应的钯非均相催化剂，对合成N-取代氨基吡啶具有较高的催化活性和良好的回收性能。
• Fioravanti; Biava; Donnarumma, Il Farmaco, 1996, vol. 51, # 10, p. 643 - 652
  作者：Fioravanti、Biava、Donnarumma、Porretta、Simonetti、Villa、Porta-Puglia、Deidda、Maullu、Pompei

  DOI：——

  日期：——
• PERCUTANEOUS ABSORPTION PREPARATIONS OF COMPOUND HAVING ANGIOTENSIN II RECEPTOR ANTAGONISM
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1153613B1

  公开（公告）日：2010-11-10
• Research on antibacterial and antifungal agents. XI. Synthesis and antimicrobial activity of N-heteroaryl benzylamines and their Schiff bases
  作者：R Fioravanti、M Biava、GC Porretta、C Landolfi、N Simonetti、A Villa、E Conte、A Porta-Puglia

  DOI：10.1016/0223-5234(96)88217-1

  日期：1995.1

  The synthesis and antimicrobial activity of new N-heteroaryl benzylamines and their Schiff bases are reported. Antifungal data were compared with those obtained with miconazole ketoconazole, enilconazole and imazalil sulfate; which showed that some of the tested compounds possessed moderate activity against strains of Candida albicans, Candida sp and good activity against isolates of plant pathogenic fungi, In contrast the synthesized compounds showed poor antibacterial activity, except for 3j which exhibited a better activity than nalidixic acid used as positive control. The results obtained are discussed on the basis of structure-activity relationships.