methyl 3-(4-hydroxybenzyl)benzoate | 123692-42-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3-(4-hydroxybenzyl)benzoate
• 英文别名: methyl 3-[(4-hydroxyphenyl)methyl]benzoate
• CAS: 123692-42-2
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: PNGCMCLESQGOFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 3-(4-hydroxybenzyl)benzoate 在 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 以864 mg的产率得到3-(4-hydroxybenzyl)benzoic acid
  参考文献：
  名称：

  Short pseudopeptides containing turn scaffolds with high AT2 receptor affinity

  摘要：

  Two pentapeptides, Ac-Tyr-Ile-His-Pro-Phe/Ile, were synthesized and shown to have angiotensin II AT(2) receptor affinity and agonistic activity. Based on these peptides, a new series of 13 pseudopeptides was synthesized via introduction of five different turn scaffolds replacing the Tyr-Ile amino acid residues. Pharmacological evaluation disclosed subnanomolar affinities for some of these compounds at the AT(2) receptor. Substitution of Phe by Ile in this series of ligands enhanced the AT(2) receptor affinity of all compounds. These results suggest that the C-terminal amino acid residues can be elaborated on to enhance the AT(2) receptor affinity in truncated Ang II analogues. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.05.019
• 作为产物：
  描述：

  methyl 3-(4-methoxybenzyl)benzoate 在 三氟二甲基硫醚络合物 作用下， 以 二氯甲烷 为溶剂， 生成 methyl 3-(4-hydroxybenzyl)benzoate
  参考文献：
  名称：

  Short pseudopeptides containing turn scaffolds with high AT2 receptor affinity

  摘要：

  Two pentapeptides, Ac-Tyr-Ile-His-Pro-Phe/Ile, were synthesized and shown to have angiotensin II AT(2) receptor affinity and agonistic activity. Based on these peptides, a new series of 13 pseudopeptides was synthesized via introduction of five different turn scaffolds replacing the Tyr-Ile amino acid residues. Pharmacological evaluation disclosed subnanomolar affinities for some of these compounds at the AT(2) receptor. Substitution of Phe by Ile in this series of ligands enhanced the AT(2) receptor affinity of all compounds. These results suggest that the C-terminal amino acid residues can be elaborated on to enhance the AT(2) receptor affinity in truncated Ang II analogues. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.05.019

文献信息

• Quinoline derivatives as antagonists of leukotriene D.sub.4
  申请人：Rhone-Poulenc Rorer Pharmaceuticals Inc.

  公开号：US05051427A1

  公开（公告）日：1991-09-24

  This invention relates to certain quinoline-diaryl compounds and their use as leukotriene D.sub.4 antagonists for the treatment of hypersensitive disorders.

  这项发明涉及某些喹啉-二芳基化合物及其作为白三烯D.sub.4拮抗剂用于治疗过敏性疾病。
• Quinoline derivatives and use thereof as antagonists of leukotriene D.sub.4
  申请人：Rorer Pharmaceutical Corp.

  公开号：US04920133A1

  公开（公告）日：1990-04-24

  This invention relates to certain quinoline-diaryl compounds and their use as leukotriene D.sub.4 antagonists for the treatment of hypersensitive disorders.

  本发明涉及某些喹啉-二芳基化合物及其作为白三烯D.sub.4拮抗剂治疗过敏性疾病的用途。
• HUANG, FU-CHI;GALEMMO, ROBERT A. (JR);CAMPBELL, HENRY F.
  作者：HUANG, FU-CHI、GALEMMO, ROBERT A. (JR)、CAMPBELL, HENRY F.

  DOI：——

  日期：——
• EP0395697A4
  申请人：——

  公开号：EP0395697A4

  公开（公告）日：1991-03-13
• QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4?
  申请人：RORER INTERNATIONAL (OVERSEAS) INC.

  公开号：EP0395697A1

  公开（公告）日：1990-11-07